Effect of pulsed radiofrequency for postherpetic neuralgia

Effect of pulsed radiofrequency for postherpetic neuralgia Background: Postherpetic neuralgia (PHN) is one of the most intractable pain disorders, particularly among elderly patients. Lesioning of dorsal root ganglion (DRG) using pulsed radiofrequency (PRF) has shown pain reduction for PHN. We assessed the efficacy of PRF lesioning of DRG for PHN via an open, nonrandomized study. Methods: Forty‐nine patients with PHN refractory to conservative therapy were involved. After impedance and sensory electrical nerve stimulation thresholds were assessed, PRF was performed three times adjacent to the DRG of corresponding levels at 42 °C for 120 s under the fluoroscopic guidance. Pain ratings were conducted on a visual analogue scale at 4‐, 8‐ and 12‐week follow‐up. The data were analyzed using the one‐way ANOVA test. P<0.05 was considered to be statistically significant. Results: There was excellent pain relief (about 55%) at 4 weeks after PRF lesioning adjacent to the DRG and the effectiveness was maintained at the subsequent 12‐week follow‐up. The pain duration, age and stimulation level did not influence the outcome. There were no procedure‐related complications. Conclusions: PRF lesioning of DRG showed significant pain relief compared with the conventional treatments in patients with intractable PHN. In order to elucidate the mode of action of PRF, further research is needed and the optimal electrical parameters of PRF have to be determined. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Anaesthesiologica Scandinavica Wiley

Effect of pulsed radiofrequency for postherpetic neuralgia

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Publisher
Wiley
Copyright
© 2008 The Authors. Journal compilation © 2008 The Acta Anaesthesiologica Scandinavica Foundation
ISSN
0001-5172
eISSN
1399-6576
DOI
10.1111/j.1399-6576.2008.01752.x
pmid
18840116
Publisher site
See Article on Publisher Site

Abstract

Background: Postherpetic neuralgia (PHN) is one of the most intractable pain disorders, particularly among elderly patients. Lesioning of dorsal root ganglion (DRG) using pulsed radiofrequency (PRF) has shown pain reduction for PHN. We assessed the efficacy of PRF lesioning of DRG for PHN via an open, nonrandomized study. Methods: Forty‐nine patients with PHN refractory to conservative therapy were involved. After impedance and sensory electrical nerve stimulation thresholds were assessed, PRF was performed three times adjacent to the DRG of corresponding levels at 42 °C for 120 s under the fluoroscopic guidance. Pain ratings were conducted on a visual analogue scale at 4‐, 8‐ and 12‐week follow‐up. The data were analyzed using the one‐way ANOVA test. P<0.05 was considered to be statistically significant. Results: There was excellent pain relief (about 55%) at 4 weeks after PRF lesioning adjacent to the DRG and the effectiveness was maintained at the subsequent 12‐week follow‐up. The pain duration, age and stimulation level did not influence the outcome. There were no procedure‐related complications. Conclusions: PRF lesioning of DRG showed significant pain relief compared with the conventional treatments in patients with intractable PHN. In order to elucidate the mode of action of PRF, further research is needed and the optimal electrical parameters of PRF have to be determined.

Journal

Acta Anaesthesiologica ScandinavicaWiley

Published: Sep 1, 2008

References

  • Characteristics and mode of action of radiofrequency lesions
    Sluijiter, Sluijiter; Van Kleef, Van Kleef
  • Effect of pulsed versus conventional radiofrequency current on rabbit dorsal root ganglion morphology
    Erdine, Erdine; Yucel, Yucel; Cimen, Cimen

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