Effect of percutaneous absorption of hydrocortisone on adrenocortical responsiveness in infants with severe skin disease

Effect of percutaneous absorption of hydrocortisone on adrenocortical responsiveness in infants... SUMMARY Percutaneous absorption of hydrocortisone was studied in 18 children (aged from 6 weeks to 14½ years) with atopic or seborrhoeic dermatitis, by measuring their serum cortisol before and after application of 1% hydrocortisone cream. Endogenous secretion of cortisol was suppressed with dexamethasone. A 24 h absorption test was performed on nine children. In six, percutaneous absorption was detected. The highest serum cortisol level was reached within the first 6 h. A 4 h absorption test was developed on the basis of the 24 h test. This short absorption test was performed on nine children, and in eight of them absorption of hydrocortisone was detected. The rise of serum cortisol ranged from 98 to 2669 nmol/1. The 2 h ACTH test was performed to evaluate the effect of previous treatment with topical glucocorticoids. Suppressed adrenocortical function was found in five of 13 children, and was associated significantly with high post‐application serum cortisol levels. This occured more often in infants with a severe skin disorder than in older children or in those with mild or moderate skin disease. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Dermatology Wiley

Effect of percutaneous absorption of hydrocortisone on adrenocortical responsiveness in infants with severe skin disease

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Publisher
Wiley
Copyright
Copyright © 1986 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0007-0963
eISSN
1365-2133
DOI
10.1111/j.1365-2133.1986.tb06242.x
Publisher site
See Article on Publisher Site

Abstract

SUMMARY Percutaneous absorption of hydrocortisone was studied in 18 children (aged from 6 weeks to 14½ years) with atopic or seborrhoeic dermatitis, by measuring their serum cortisol before and after application of 1% hydrocortisone cream. Endogenous secretion of cortisol was suppressed with dexamethasone. A 24 h absorption test was performed on nine children. In six, percutaneous absorption was detected. The highest serum cortisol level was reached within the first 6 h. A 4 h absorption test was developed on the basis of the 24 h test. This short absorption test was performed on nine children, and in eight of them absorption of hydrocortisone was detected. The rise of serum cortisol ranged from 98 to 2669 nmol/1. The 2 h ACTH test was performed to evaluate the effect of previous treatment with topical glucocorticoids. Suppressed adrenocortical function was found in five of 13 children, and was associated significantly with high post‐application serum cortisol levels. This occured more often in infants with a severe skin disorder than in older children or in those with mild or moderate skin disease.

Journal

British Journal of DermatologyWiley

Published: Oct 1, 1986

References

  • Percutaneous absorption of topical steroids in children
    Feiwel, Feiwel

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