Effect of olive oil phenolic compounds on osteoblast differentiation

Effect of olive oil phenolic compounds on osteoblast differentiation INTRODUCTIONBone metabolic diseases develop when there is an imbalance between the formation and resorption of bone that depends on the interaction between osteoblasts and osteoclasts. Osteoporosis is the most common bone metabolic disease in adults, especially among the elderly, which is characterized by compromised bone strength that predisposes individuals to an increased risk of fracture. Most current pharmacological approaches focus on inhibiting bone resorption in patients with osteoporosis or at risk of developing the disease. However, researchers have also provided evidence on dietary components that can optimize bone mass and stimulate bone formation. Thus, Habauzit & Horcajada reported that phytonutrients in our diet, especially polyphenols, can act on both osteoblasts and osteoclasts to modulate bone metabolism.Bone formation involves a complex series of events, including osteoprogenitor cell proliferation and differentiation, which eventually result in the formation of a mineralized extracellular matrix. Numerous cytokines, hormones and growth factors control bone formation by regulating osteoblast cell proliferation and differentiation. Bone is a dynamic tissue under continuous remodelling process where osteoblasts, which derive from undifferentiated pluripotent mesenchymal cells, are responsible for bone development. It has been described that osteoblasts have immunological functions because of the expression of markers of antigen‐presenting capacity (CD54, CD80, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Clinical Investigation Wiley
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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd
ISSN
0014-2972
eISSN
1365-2362
D.O.I.
10.1111/eci.12904
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONBone metabolic diseases develop when there is an imbalance between the formation and resorption of bone that depends on the interaction between osteoblasts and osteoclasts. Osteoporosis is the most common bone metabolic disease in adults, especially among the elderly, which is characterized by compromised bone strength that predisposes individuals to an increased risk of fracture. Most current pharmacological approaches focus on inhibiting bone resorption in patients with osteoporosis or at risk of developing the disease. However, researchers have also provided evidence on dietary components that can optimize bone mass and stimulate bone formation. Thus, Habauzit & Horcajada reported that phytonutrients in our diet, especially polyphenols, can act on both osteoblasts and osteoclasts to modulate bone metabolism.Bone formation involves a complex series of events, including osteoprogenitor cell proliferation and differentiation, which eventually result in the formation of a mineralized extracellular matrix. Numerous cytokines, hormones and growth factors control bone formation by regulating osteoblast cell proliferation and differentiation. Bone is a dynamic tissue under continuous remodelling process where osteoblasts, which derive from undifferentiated pluripotent mesenchymal cells, are responsible for bone development. It has been described that osteoblasts have immunological functions because of the expression of markers of antigen‐presenting capacity (CD54, CD80,

Journal

European Journal of Clinical InvestigationWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

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