Effect of nephrectomy for retroperitoneal sarcoma on post‐operative renal function

Effect of nephrectomy for retroperitoneal sarcoma on post‐operative renal function AbbreviationsGFRGlomerular filtration rateRPSRetroperitoneal sarcomaCKDChronic kidney diseaseINTRODUCTIONRetroperitoneal sarcomas (RPS) are relatively uncommon, representing less than 1% of annual cancer incidences. Current available chemotherapy regimens and radiation therapy for RPS have shown questionable survival benefit. Surgery remains the cornerstone of treatment for these malignancies with a R0 resection offering the only chance for cure.Controversy exists surrounding the ideal surgical management of RPS, specifically the indications for nephrectomy during en‐bloc resection. Five‐year local recurrence rates have been reported to be 31–63%, stressing the importance of a complete resection and its associated increased survival. Given this, some authors argue for an aggressive compartmental operative approach that often involves nephrectomy, as past evidence has shown improved loco‐regional control with this approach.Other authors contend that surgical strategy should be individualized based on histology and the relationship the tumor has within the anatomically complex retroperitoneal cavity. They cite the potential morbidity and mortality associated with an aggressive multi‐visceral approach to RPS. In particular, they argue there is a potential long‐term risk of chronic kidney disease (CKD) associated with those patients undergoing nephrectomy as well as the limitations this may impose on adjuvant treatment. Few would argue against a nephrectomy as part of en‐bloc RPS resection with http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Surgical Oncology Wiley

Effect of nephrectomy for retroperitoneal sarcoma on post‐operative renal function

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Wiley Periodicals, Inc.
ISSN
0022-4790
eISSN
1096-9098
D.O.I.
10.1002/jso.24875
Publisher site
See Article on Publisher Site

Abstract

AbbreviationsGFRGlomerular filtration rateRPSRetroperitoneal sarcomaCKDChronic kidney diseaseINTRODUCTIONRetroperitoneal sarcomas (RPS) are relatively uncommon, representing less than 1% of annual cancer incidences. Current available chemotherapy regimens and radiation therapy for RPS have shown questionable survival benefit. Surgery remains the cornerstone of treatment for these malignancies with a R0 resection offering the only chance for cure.Controversy exists surrounding the ideal surgical management of RPS, specifically the indications for nephrectomy during en‐bloc resection. Five‐year local recurrence rates have been reported to be 31–63%, stressing the importance of a complete resection and its associated increased survival. Given this, some authors argue for an aggressive compartmental operative approach that often involves nephrectomy, as past evidence has shown improved loco‐regional control with this approach.Other authors contend that surgical strategy should be individualized based on histology and the relationship the tumor has within the anatomically complex retroperitoneal cavity. They cite the potential morbidity and mortality associated with an aggressive multi‐visceral approach to RPS. In particular, they argue there is a potential long‐term risk of chronic kidney disease (CKD) associated with those patients undergoing nephrectomy as well as the limitations this may impose on adjuvant treatment. Few would argue against a nephrectomy as part of en‐bloc RPS resection with

Journal

Journal of Surgical OncologyWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

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