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EFFECT OF ETYA AND BW 755c ON ARACHIDONATE‐INDUCED CONTRACTIONS IN THE GUINEA‐PIG ISOLATED TRACHEA

EFFECT OF ETYA AND BW 755c ON ARACHIDONATE‐INDUCED CONTRACTIONS IN THE GUINEA‐PIG ISOLATED TRACHEA 1 Arachidonic acid caused larger contractions in indomethacin‐treated guinea‐pig trachea than in control tracheae. 2 No change in contractions was obtained in tracheae treated with 5, 8, 11, 14, eicosatetraynoic acid (ETYA 10 μm). 3 ETYA (100 μm) blocked the effect of indomethacin on arachidonic acid‐induced responses. Likewise BW 755c (113 μm) reversed the effect of indomethacin. 4 The results show that arachidonate lipoxygenase products may be responsible for the contractile responses seen in the presence of indomethacin. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Pharmacology Wiley

EFFECT OF ETYA AND BW 755c ON ARACHIDONATE‐INDUCED CONTRACTIONS IN THE GUINEA‐PIG ISOLATED TRACHEA

British Journal of Pharmacology , Volume 76 (4) – Aug 1, 1982

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Publisher
Wiley
Copyright
1982 British Pharmacological Society
ISSN
0007-1188
eISSN
1476-5381
DOI
10.1111/j.1476-5381.1982.tb09250.x
Publisher site
See Article on Publisher Site

Abstract

1 Arachidonic acid caused larger contractions in indomethacin‐treated guinea‐pig trachea than in control tracheae. 2 No change in contractions was obtained in tracheae treated with 5, 8, 11, 14, eicosatetraynoic acid (ETYA 10 μm). 3 ETYA (100 μm) blocked the effect of indomethacin on arachidonic acid‐induced responses. Likewise BW 755c (113 μm) reversed the effect of indomethacin. 4 The results show that arachidonate lipoxygenase products may be responsible for the contractile responses seen in the presence of indomethacin.

Journal

British Journal of PharmacologyWiley

Published: Aug 1, 1982

References

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