Effect of Collicular Proteoglycan on the Survival of Adult Rat Retinal Ganglion Cells Following Axotomy

Effect of Collicular Proteoglycan on the Survival of Adult Rat Retinal Ganglion Cells Following... Consistent with numerous previous studies, we have found that in adult rats 29% of cells retrogradely prelabelled by injections into retino‐recipient nuclei are lost 1 week after intraorbital section of the optic nerve. This figure increases to 76% 2 weeks after axotomy. Intraocular injections of 150 ng of 480 kda chondroitin sulphate proteoglycan purified from the superior colliculi of neonatal rats were performed every third day after axotomy. This procedure resulted in the loss of only 3 and 28% of the axotomized retinal ganglion cells 7 and 14 days respectively after optic nerve section. Intraocular injections of chondroitin sulphate type C, one of the sugar types present on the collicular proteoglycan, also resulted in a significant saving of axotomized ganglion cells (with the loss of only 48% 14 days after optic nerve lesion). These findings suggest that the collicular proteoglycan, and to a lesser extent its sugar moieties, substantially slows down the degeneration of adult retinal ganglion cells following axotomy. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Neuroscience Wiley

Effect of Collicular Proteoglycan on the Survival of Adult Rat Retinal Ganglion Cells Following Axotomy

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Publisher
Wiley
Copyright
Copyright © 1995 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0953-816X
eISSN
1460-9568
DOI
10.1111/j.1460-9568.1995.tb01024.x
Publisher site
See Article on Publisher Site

Abstract

Consistent with numerous previous studies, we have found that in adult rats 29% of cells retrogradely prelabelled by injections into retino‐recipient nuclei are lost 1 week after intraorbital section of the optic nerve. This figure increases to 76% 2 weeks after axotomy. Intraocular injections of 150 ng of 480 kda chondroitin sulphate proteoglycan purified from the superior colliculi of neonatal rats were performed every third day after axotomy. This procedure resulted in the loss of only 3 and 28% of the axotomized retinal ganglion cells 7 and 14 days respectively after optic nerve section. Intraocular injections of chondroitin sulphate type C, one of the sugar types present on the collicular proteoglycan, also resulted in a significant saving of axotomized ganglion cells (with the loss of only 48% 14 days after optic nerve lesion). These findings suggest that the collicular proteoglycan, and to a lesser extent its sugar moieties, substantially slows down the degeneration of adult retinal ganglion cells following axotomy.

Journal

European Journal of NeuroscienceWiley

Published: Jan 1, 1995

References

  • Trophic factors produced by retinal cells increase the survival of retinal ganglion cells in vitro
    Araujo, Araujo; Linden, Linden
  • Transplant of embryonal nervous tissue preserves the responses of rat retinal ganglion cells after section of the optic nerve
    Gravina, Gravina; Domenici, Domenici; Berardi, Berardi; Galli, Galli; Maffei, Maffei
  • Electroretinographic responses and retrograde changes of retinal morphology after intracranial optic nerve section. Quantitative analysis in the cat
    Holländer, Holländer; Bisti, Bisti; Maffei, Maffei; Hebel, Hebel
  • Long term survival of cat retinal ganglion cells after intracranial optic nerve transection
    Holländer, Holländer; Bisti, Bisti; Maffei, Maffei
  • Long‐term induction of c ‐jun mRNA and Jun protein in rabbit retinal ganglion cells following axotomy or colchicine treatment
    Koistinaho, Koistinaho; Hicks, Hicks; Sagar, Sagar
  • The survival of rat retinal ganglion cells in vitro is enhanced in the presence of appropriate parts of the brain
    McCaffery, McCaffery; Bennett, Bennett; Dreher, Dreher
  • In vitro protein synthesis in the goldfish retinotectal pathway during regeneration: evidence for specific axonal proteins of retinal origin in the optic nerve
    Quitschke, Quitschke; Schechter, Schechter
  • A retinal ganglion cell neurotrophic factor purified from the superior colliculus
    Schulz, Schulz; Raju, Raju; Ralston, Ralston; Bennett, Bennett
  • Quantitative and morphological studies on developing axons in normal and enucleated albino rats
    Sefton, Sefton; Lam, Lam

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