Early age at onset of bipolar disorder is associated with more severe clinical features but delayed treatment seeking

Early age at onset of bipolar disorder is associated with more severe clinical features but... Objective: Our aim was to obtain a comprehensive view of differences between bipolar disorder (BD) patients with onset at early versus adult age in a representative study cohort. Methods: In the Jorvi Bipolar Study (JoBS), 1,630 psychiatric in‐ and outpatients were systematically screened for BD using the Mood Disorder Questionnaire (MDQ). A total of 191 bipolar I and II patients with a current DSM‐IV episode were interviewed to obtain information about age at onset of mood symptoms, clinical course, treatment, comorbidity, and functional status. The patients were classified as either early onset (<18 years) or adult onset. Results: One‐third of subjects with BD (58/191, 30%) had early onset. This was associated with female gender, more lifetime psychotic symptoms, greater overall comorbidity, and a greater length of time from first episode to treatment. Conclusions: Although BD patients with early age at onset have more severe clinical features and illness course, the delays from first episode to treatment and to correct diagnosis are longer than for those with adult onset disorder. To reduce morbidity rates related to the most severe forms of BD, the recognition and diagnosis of BD during adolescence needs to be improved. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Bipolar Disorders Wiley

Early age at onset of bipolar disorder is associated with more severe clinical features but delayed treatment seeking

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Publisher
Wiley
Copyright
Copyright © 2007 Wiley Subscription Services, Inc., A Wiley Company
ISSN
1398-5647
eISSN
1399-5618
D.O.I.
10.1111/j.1399-5618.2007.00388.x
Publisher site
See Article on Publisher Site

Abstract

Objective: Our aim was to obtain a comprehensive view of differences between bipolar disorder (BD) patients with onset at early versus adult age in a representative study cohort. Methods: In the Jorvi Bipolar Study (JoBS), 1,630 psychiatric in‐ and outpatients were systematically screened for BD using the Mood Disorder Questionnaire (MDQ). A total of 191 bipolar I and II patients with a current DSM‐IV episode were interviewed to obtain information about age at onset of mood symptoms, clinical course, treatment, comorbidity, and functional status. The patients were classified as either early onset (<18 years) or adult onset. Results: One‐third of subjects with BD (58/191, 30%) had early onset. This was associated with female gender, more lifetime psychotic symptoms, greater overall comorbidity, and a greater length of time from first episode to treatment. Conclusions: Although BD patients with early age at onset have more severe clinical features and illness course, the delays from first episode to treatment and to correct diagnosis are longer than for those with adult onset disorder. To reduce morbidity rates related to the most severe forms of BD, the recognition and diagnosis of BD during adolescence needs to be improved.

Journal

Bipolar DisordersWiley

Published: Nov 1, 2007

References

  • Early age at onset as a risk factor for poor outcome of bipolar disorder
    Carter, Carter; Mundo, Mundo; Parikh, Parikh; Kennedy, Kennedy
  • Review and meta‐analysis of the phenomenology and clinical characteristics of mania in children and adolescents
    Kowatch, Kowatch; Youngstrom, Youngstrom; Danielyan, Danielyan; Findling, Findling
  • A prospective 4–5‐year follow‐up of juvenile onset bipolar disorder
    Jairam, Jairam; Srinath, Srinath; Girimaji, Girimaji; Seshadri, Seshadri
  • The clinical characteristics of DSM‐IV bipolar I and II disorders: baseline findings from the Jorvi Bipolar Study (JoBS)
    Mantere, Mantere; Suominen, Suominen; Leppämäki, Leppämäki; Valtonen, Valtonen; Arvilommi, Arvilommi; Isometsä, Isometsä
  • Age at onset in bipolar affective disorders: a review
    Leboyer, Leboyer; Henry, Henry; Paillere‐Martinot, Paillere‐Martinot; Bellivier, Bellivier
  • Age at onset of bipolar II depressive mixed state
    Benazzi, Benazzi
  • Treatment‐latency and previous episodes: relationships to pretreatment morbidity and response to maintenance treatment in bipolar I and II disorders
    Baldessarini, Baldessarini; Tondo, Tondo; Hennen, Hennen

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