Dye‐Coupling in the neostriatum of the rat: II. Decreased coupling between neurons during development

Dye‐Coupling in the neostriatum of the rat: II. Decreased coupling between neurons during... Physiological and morphological evidence for coupling between neostriatal neurons was obtained from the developing rat. Intracellular injections of Lucifer Yellow‐CH (LY) were made in rat neostriatal slices to study dye transfer (coupling) between neurons. The incidence of interneuronal coupling was 70% in early postnatal (P) periods and declined gradually to 10% in the adult. The number of neurons filled by a single intracellular injection also declined with age. LY injection into single neurons commonly marked aggregates of 4 to 6 cells in neonates. Single injections never produced more than one coupled pair in P20 or older rats. Neurons in which fast prepotentials (FPPs) could be evoked were consistently found to be dye‐coupled. FPPs were resistant to collision with action potentials generated by intracellular current injection. When chemical synaptic transmission was blocked by Mn2+, short‐latency depolarization (SLDs) could be evoked by extracellular stimulation. The SLDs were distinguished from chemical synaptic potentials by their “all or none” nature and by their insensitivity to changes in membrane potential. No SLDs were observed in adult neurons. FPPs and SLDs may be indicators of electrotonic transmission between coupled cells. The high incidence of coupling early in development might reflect intercellular communication that contributes to the differentiation and growth of neostriatal neurons. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Synapse Wiley

Dye‐Coupling in the neostriatum of the rat: II. Decreased coupling between neurons during development

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Publisher
Wiley
Copyright
Copyright © 1989 Alan R. Liss, Inc.
ISSN
0887-4476
eISSN
1098-2396
D.O.I.
10.1002/syn.890040309
Publisher site
See Article on Publisher Site

Abstract

Physiological and morphological evidence for coupling between neostriatal neurons was obtained from the developing rat. Intracellular injections of Lucifer Yellow‐CH (LY) were made in rat neostriatal slices to study dye transfer (coupling) between neurons. The incidence of interneuronal coupling was 70% in early postnatal (P) periods and declined gradually to 10% in the adult. The number of neurons filled by a single intracellular injection also declined with age. LY injection into single neurons commonly marked aggregates of 4 to 6 cells in neonates. Single injections never produced more than one coupled pair in P20 or older rats. Neurons in which fast prepotentials (FPPs) could be evoked were consistently found to be dye‐coupled. FPPs were resistant to collision with action potentials generated by intracellular current injection. When chemical synaptic transmission was blocked by Mn2+, short‐latency depolarization (SLDs) could be evoked by extracellular stimulation. The SLDs were distinguished from chemical synaptic potentials by their “all or none” nature and by their insensitivity to changes in membrane potential. No SLDs were observed in adult neurons. FPPs and SLDs may be indicators of electrotonic transmission between coupled cells. The high incidence of coupling early in development might reflect intercellular communication that contributes to the differentiation and growth of neostriatal neurons.

Journal

SynapseWiley

Published: Jan 1, 1989

References

  • Electrotonic coupling between neurons in the rat mesencephalic nucleus
    Baker, Baker; Llinás, Llinás
  • The role of gap junctions in development
    Caveney, Caveney
  • Dye‐coupling in the neostriatum of the rat: I. Modulation by dopamine depleting lesions
    Cepeda, Cepeda; Walsh, Walsh; Hull, Hull; Howard, Howard; Buchwald, Buchwald; Levine, Levine
  • Membrane‐fusions and cytoplasmic bridges in the cells of the developing cerebellum
    Das, Das
  • The development of electrical properties of identified neurons in grasshopper embryos
    Goodman, Goodman; Spitzer, Spitzer
  • Multiple receptors for dopamine
    Kebabian, Kebabian; Calne, Calne
  • Electrotonic coupling between neurons in the rat vestibular nucleus
    Korn, Korn; Sotelo, Sotelo; Crepel, Crepel
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    Llinás, Llinás; Baker, Baker; Sotelo, Sotelo
  • Electrotonic coupling between granule cells of rat dentate gyrus: Physiological and anatomical evidence
    MacVicar, MacVicar; Dudek, Dudek
  • Developmental modulation of electrical synapse
    Rayport, Rayport; Kandel, Kandel
  • Neuronal arrangement in the auditory field L of the neostriatum of the starling
    Saini, Saini; Leppelsack, Leppelsack
  • Development of somatosensory responsiveness in basal ganglia in awake cats
    Schneider, Schneider; Levine, Levine; Hull, Hull; Buchwald, Buchwald
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    Spencer, Spencer; Kandel, Kandel
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    Traub, Traub; Llinás, Llinás

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