Duodenal localization is a negative predictor of survival after small bowel adenocarcinoma resection: A population‐based, propensity score‐matched analysis

Duodenal localization is a negative predictor of survival after small bowel adenocarcinoma... INTRODUCTIONSmall bowel neoplasms are rather rare and account for approximately 3% of all gastrointestinal tract malignancies in the US. More than 9000 new cases are reported annually. These malignant tumors are primarily adenocarcinomas or carcinoids and occur at a rate of approximately 37% each. The remaining tumors are lymphomas and stromal tumors that account for approximately 17% and 8%, respectively. These tumor entities are not equally distributed along the small bowel. For example, adenocarcinomas occur more frequently in the duodenum.Most patients suffering from adenocarcinoma of the small bowel initially present only nonspecific symptoms. Therefore, diagnosis is often delayed and occurs at laparotomy or by the pathologist. Small bowel adenocarcinomas are commonly diagnosed in an advanced stage and with distant metastases.Treatment of localized disease is primarily based on surgical resection. Adjuvant chemotherapy, radiotherapy or both may be beneficial in select cases, but evidence of any benefit is poor. Surgery for metastatic disease is only useful for alleviating symptoms via resection of obstructing or bleeding primaries. Palliative chemotherapy exerts some effect according to small studies and is recommended.An adenoma‐cancer sequence is observed for small bowel adenocarcinoma, similar to colorectal cancer (CRC). CRC and adenocarcinoma of the small bowel are genetically similar, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Surgical Oncology Wiley

Duodenal localization is a negative predictor of survival after small bowel adenocarcinoma resection: A population‐based, propensity score‐matched analysis

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Wiley Periodicals, Inc.
ISSN
0022-4790
eISSN
1096-9098
D.O.I.
10.1002/jso.24877
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONSmall bowel neoplasms are rather rare and account for approximately 3% of all gastrointestinal tract malignancies in the US. More than 9000 new cases are reported annually. These malignant tumors are primarily adenocarcinomas or carcinoids and occur at a rate of approximately 37% each. The remaining tumors are lymphomas and stromal tumors that account for approximately 17% and 8%, respectively. These tumor entities are not equally distributed along the small bowel. For example, adenocarcinomas occur more frequently in the duodenum.Most patients suffering from adenocarcinoma of the small bowel initially present only nonspecific symptoms. Therefore, diagnosis is often delayed and occurs at laparotomy or by the pathologist. Small bowel adenocarcinomas are commonly diagnosed in an advanced stage and with distant metastases.Treatment of localized disease is primarily based on surgical resection. Adjuvant chemotherapy, radiotherapy or both may be beneficial in select cases, but evidence of any benefit is poor. Surgery for metastatic disease is only useful for alleviating symptoms via resection of obstructing or bleeding primaries. Palliative chemotherapy exerts some effect according to small studies and is recommended.An adenoma‐cancer sequence is observed for small bowel adenocarcinoma, similar to colorectal cancer (CRC). CRC and adenocarcinoma of the small bowel are genetically similar,

Journal

Journal of Surgical OncologyWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

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