AbbreviationsACSacute coronary syndromeAMIacute myocardial infarctionBARCbleeding academic research consortiumCADcoronary artery diseaseCRcomplete revascularization;DAPTdual antiplatelet therapyDESdrug‐eluting stentIRincomplete revascularizationMACCEmajor adverse cardiovascular and cerebrovascular eventsMImyocardial infarctionORodds ratiosPCIpercutaneous coronary interventionSTstent thrombosisTVRtarget vessel revascularizationINTRODUCTIONDual antiplatelet therapy (DAPT), aspirin in combination with a P2Y12 antagonist, is an essential component of the treatment of patients undergoing percutaneous coronary intervention (PCI), particularly with a drug‐eluting stent (DES) . Therefore, a minimum DAPT duration of 12 months after DES implantation was recommended by guidelines, regardless of reported clinical research results . However, with the advent of new generation DESs, which are associated with a consistent reduction in stent thrombosis (ST) compared with first‐generation DESs , the optimal duration of DAPT is under debate. Although a reduced DAPT duration was considered safe and with a reduced risk of bleeding complications , ST after more than 12 months after DES implantation was observed . Thus, updated guidelines with adjusted DAPT duration after DES implantation has been recommended, according to the patients' bleeding and ischemic risks .For real clinical cases, DAPT duration after DES implantation is more complicated, determined by both physicians' comprehension of the complex guidelines and the patients' compliance . Data from the PARIS (patterns of nonadherence to antiplatelet regimens in stented
Catheterization and Cardiovascular Interventions – Wiley
Published: Jan 15, 2018
Keywords: ; ;
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