DECEMBER 1988 Drug receptors and the inhibition of nerve cells R. Alan North Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, U.S.A. Introduction It would be trite indeed to say much to this audience of the contributions to pharmacology made by Sir John Gaddum. His quantitative approaches to the study of drug antagonism have found their way into most textbooks of pharmacology. I dare say that, if asked to define that aspect of the subject which is uniquely 'pharmacology'-a task of increasing difficulty in these interdisciplinary days-many Society members would think first of those quantitative methods for studying drug-receptor interactions spawned by A.J. Clark, tested with antagonists by John Gaddum, and much popularized by Heinz Schild (Clark, 1933; Gaddum, 1937; 1957; Schild, 1949). I thank the Trustees for providing me with the opportunity to add my own small tribute to the memory of John Gaddum's work; this is particularly so because-as you will see-my own research has been much influenced by his contributions. John Gaddum worked mostly with peripheral tissues. This was convenient because the tissues were readily accessible, easy to maintain in vitro, and in those days devites could be made to measure the appropriate response,
British Journal of Pharmacology – Wiley
Published: Sep 1, 1989
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