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Drosophila longevity is not affected by heterochromatin-mediated gene silencing

Two highly conserved histone deacetylases have been implicated in extending the longevity of model organisms, Sir2 and Rpd3 ( Guarente & Kenyon, 2000 ; Rogina et al ., 2002 ). Histone deacetylases contribute to the regulation of nucleosome compaction and gene silencing in both euchromatin, the region that contains most functional genes, and heterochromatin, regions thought to be highly compact and to consist primarily of simple repeat sequences ( Richards & Elgin, 2002 ; Yang & Seto, 2003 ). Specifically, in Drosophila Melanogaster and other model systems Sir2 and Rpd3 can act in euchromatin, co-repressing defined sets of target genes ( Pile & Wassarman, 2000 ; van Steensel et al. , 2001 ; Kurdistani et al. , 2002 ; Robyr et al. , 2002 ), and in heterochromatin, modulating the architecture of large genomic regions ( Mottus et al ., 2000 ; Pile & Wassarman, 2000 ; Chang et al ., 2001 ; Czermin et al ., 2001 ; Tie et al ., 2001 ; Newman et al ., 2002 ; Pile et al ., 2002 ; Astrom et al ., 2003 ). A special form of gene silencing known as position-effect variegation (PEV) is observed when chromosome http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Aging Cell Wiley

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