Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Drosophila Hox complex downstream targets and the function of homeotic genes

Drosophila Hox complex downstream targets and the function of homeotic genes Hox complex genes are key developmental regulators highly conserved throughout evolution. The encoded proteins share a 60‐amino‐acid DNA‐binding motif, the homeodomain, and function as transcription factors to control axial patterning. An important question concerns the nature and function of genes acting downstream of Hox proteins. This review focuses on Drosophila, as little is known about this question in other organisms. The noticeable progress gained in the field during the past few years has significantly improved our current understanding of how Hox genes control diversified morphogenesis. Here we summarise the strategies deployed to identify Hox target genes and discuss how their function contributes to pattern formation and morphogenesis. The regulation of target genes is also considered with special emphasis on the mechanisms underlying the specificity of action of Hox proteins in the whole animal. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png BioEssays Wiley

Drosophila Hox complex downstream targets and the function of homeotic genes

BioEssays , Volume 19 (5) – May 1, 1997

Loading next page...
 
/lp/wiley/drosophila-hox-complex-downstream-targets-and-the-function-of-homeotic-pqUnS1iMQb

References (92)

Publisher
Wiley
Copyright
Copyright © 1997 Cambridge University Press
ISSN
0265-9247
eISSN
1521-1878
DOI
10.1002/bies.950190505
pmid
9174403
Publisher site
See Article on Publisher Site

Abstract

Hox complex genes are key developmental regulators highly conserved throughout evolution. The encoded proteins share a 60‐amino‐acid DNA‐binding motif, the homeodomain, and function as transcription factors to control axial patterning. An important question concerns the nature and function of genes acting downstream of Hox proteins. This review focuses on Drosophila, as little is known about this question in other organisms. The noticeable progress gained in the field during the past few years has significantly improved our current understanding of how Hox genes control diversified morphogenesis. Here we summarise the strategies deployed to identify Hox target genes and discuss how their function contributes to pattern formation and morphogenesis. The regulation of target genes is also considered with special emphasis on the mechanisms underlying the specificity of action of Hox proteins in the whole animal.

Journal

BioEssaysWiley

Published: May 1, 1997

There are no references for this article.