INTRODUCTIONGastric cancer (GC) is the fourth most common cancer in man and the fifth most common cancer in women worldwide, with a high mortality. It is a multifactorial disorder that results from abnormal activation of several oncogenic signaling pathways, the activation of oncogenes, the inactivation of tumor suppressor genes and the dysregulation of cell cycle‐related proteins. However, the molecular mechanism underlying GC remains unclear.Programmed cell death, a genetically controlled process that regulates the regeneration and differentiation of gastric epithelial cells, is important for understanding the carcinogenesis of GC. As a newly found programmed cell death agent, pyroptosis is involved in various diseases, but few studies have been published regarding the relationship between pyroptosis and GC. Recent studies have focused on the gasdermin D (GSDMD) protein, which acts as the trigger of pyroptosis to maintain cell homeostasis. The collapse of this suicide process in the gastric epithelium is considered the cause of GC cell proliferation.Previous studies have shown that in upper gastrointestinal (GI) cancers the expression and function of four gasdermin (GSDM) family genes differed from each other. The GSDM family has been found to participate in the apoptotic signaling to suppress the development of GC. Furthermore, inflammasomes, functioning in
Journal of Digestive Diseases – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ; ;
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.
All for just $49/month
Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.
Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.
It’s easy to organize your research with our built-in tools.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera