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Doppler sonography of the penile cavernosal artery: Comparison of intraurethral instillation and intracorporeal injection of prostaglandin E 1

Doppler sonography of the penile cavernosal artery: Comparison of intraurethral instillation and... Purpose We compared the Doppler sonographic findings in the penile cavernosal artery (arteria profunda penis) after intraurethral instillation and intracorporeal injection of prostaglandin E1 (PGE1) to evaluate the hemodynamic changes during drug‐induced erection. Methods Twenty healthy male volunteers were enrolled in the study. Ten subjects (intraurethral group) were examined with Doppler sonography of the penile cavernosal artery after intraurethral administration of 1 mg of PGE1. The remaining 10 subjects (intracorporeal group) underwent Doppler sonography of the cavernosal artery after intracorporeal injection of 5 μg of PGE1. The peak systolic velocity, minimal diastolic velocity, and resistance index were determined at 5‐minute intervals for 30 minutes following administration of PGE1 in both groups. The results were compared between the 2 groups. Results The peak systolic velocity in the intraurethral group increased progressively from a mean of 31.1 cm/second at 5 minutes to 65.6 cm/second at 30 minutes after intraurethral administration of PGE1. In the intracorporeal group, the mean peak systolic velocity ranged from 44.1 to 83.2 cm/second, reached a maximum at 10 minutes, and then decreased continuously through 30 minutes after intracorporeal injection of PGE1. The mean peak systolic velocities were significantly higher in the intracorporeal group at 10 and 15 minutes (p ≤ 0.05); the mean minimal diastolic velocities were significantly lower in the intracorporeal group at 15, 20, and 25 minutes (p ≤ 0.05); and the mean resistance indices were significantly higher in the intracorporeal group at all time points except 5 minutes (p ≤ 0.05). Conclusions The intracorporeal injection of PGE1 produced a greater vasoactive response in the cavernosal artery than did intraurethral instillation. © 2001 John Wiley & Sons, Inc. J Clin Ultrasound 29:273–278, 2001. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Clinical Ultrasound Wiley

Doppler sonography of the penile cavernosal artery: Comparison of intraurethral instillation and intracorporeal injection of prostaglandin E 1

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References (23)

Publisher
Wiley
Copyright
Copyright © 2001 John Wiley & Sons, Inc.
ISSN
0091-2751
eISSN
1097-0096
DOI
10.1002/jcu.1033
pmid
11486321
Publisher site
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Abstract

Purpose We compared the Doppler sonographic findings in the penile cavernosal artery (arteria profunda penis) after intraurethral instillation and intracorporeal injection of prostaglandin E1 (PGE1) to evaluate the hemodynamic changes during drug‐induced erection. Methods Twenty healthy male volunteers were enrolled in the study. Ten subjects (intraurethral group) were examined with Doppler sonography of the penile cavernosal artery after intraurethral administration of 1 mg of PGE1. The remaining 10 subjects (intracorporeal group) underwent Doppler sonography of the cavernosal artery after intracorporeal injection of 5 μg of PGE1. The peak systolic velocity, minimal diastolic velocity, and resistance index were determined at 5‐minute intervals for 30 minutes following administration of PGE1 in both groups. The results were compared between the 2 groups. Results The peak systolic velocity in the intraurethral group increased progressively from a mean of 31.1 cm/second at 5 minutes to 65.6 cm/second at 30 minutes after intraurethral administration of PGE1. In the intracorporeal group, the mean peak systolic velocity ranged from 44.1 to 83.2 cm/second, reached a maximum at 10 minutes, and then decreased continuously through 30 minutes after intracorporeal injection of PGE1. The mean peak systolic velocities were significantly higher in the intracorporeal group at 10 and 15 minutes (p ≤ 0.05); the mean minimal diastolic velocities were significantly lower in the intracorporeal group at 15, 20, and 25 minutes (p ≤ 0.05); and the mean resistance indices were significantly higher in the intracorporeal group at all time points except 5 minutes (p ≤ 0.05). Conclusions The intracorporeal injection of PGE1 produced a greater vasoactive response in the cavernosal artery than did intraurethral instillation. © 2001 John Wiley & Sons, Inc. J Clin Ultrasound 29:273–278, 2001.

Journal

Journal of Clinical Ultrasound – Wiley

Published: Jun 1, 2001

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