Dopamine and Serotonin Metabolism in Brain Sites Ipsi‐ and Contralateral to Direction of Conditioned Turning in Rats

Dopamine and Serotonin Metabolism in Brain Sites Ipsi‐ and Contralateral to Direction of... Abstract: Concentrations of dopamine, serotonin, and some of their metabolites were analyzed by means of HPLC in brain samples obtained from rats operantly conditioned to turn in circles to obtain water reinforcement. In experiment 1 using Wistar rats, no differences in the levels of transmitters or metabolites were detected between brain samples (frontal cortex, ventral striatum, dorsal striatum, septum, amygdala, substantia nigra) from the hemispheres located ipsi‐ and contralateral to the direction of turning. A higher dopamine metabolism (indicated by higher metabolite/transmitter ratios) in ventral striatum, dorsal striatum, and amygdala was found after 15 min than after 5 min of turning in both hemispheres. A higher dopamine metabolism was found in water‐deprived rats compared to nondeprived rats independently of whether or not deprived rats were trained to turn for water reinforcement. In two additional experiments, no differences in dopamine metabolism were found between the ipsi‐ and contralateral striatum of Wistar rats after 25 min and Sprague‐Dawley rats after 10 min of operantly conditioned turning. The present results confirm that dopamine metabolism can change with different behavioral or physiological states; they do not support the hypothesis that conditioned turning is correlated with asymmetrical changes in the metabolism of dopamine or serotonin in the brain. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neurochemistry Wiley

Dopamine and Serotonin Metabolism in Brain Sites Ipsi‐ and Contralateral to Direction of Conditioned Turning in Rats

Journal of Neurochemistry, Volume 48 (5) – May 1, 1987

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Publisher
Wiley
Copyright
Copyright © 1987 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0022-3042
eISSN
1471-4159
D.O.I.
10.1111/j.1471-4159.1987.tb05688.x
Publisher site
See Article on Publisher Site

Abstract

Abstract: Concentrations of dopamine, serotonin, and some of their metabolites were analyzed by means of HPLC in brain samples obtained from rats operantly conditioned to turn in circles to obtain water reinforcement. In experiment 1 using Wistar rats, no differences in the levels of transmitters or metabolites were detected between brain samples (frontal cortex, ventral striatum, dorsal striatum, septum, amygdala, substantia nigra) from the hemispheres located ipsi‐ and contralateral to the direction of turning. A higher dopamine metabolism (indicated by higher metabolite/transmitter ratios) in ventral striatum, dorsal striatum, and amygdala was found after 15 min than after 5 min of turning in both hemispheres. A higher dopamine metabolism was found in water‐deprived rats compared to nondeprived rats independently of whether or not deprived rats were trained to turn for water reinforcement. In two additional experiments, no differences in dopamine metabolism were found between the ipsi‐ and contralateral striatum of Wistar rats after 25 min and Sprague‐Dawley rats after 10 min of operantly conditioned turning. The present results confirm that dopamine metabolism can change with different behavioral or physiological states; they do not support the hypothesis that conditioned turning is correlated with asymmetrical changes in the metabolism of dopamine or serotonin in the brain.

Journal

Journal of NeurochemistryWiley

Published: May 1, 1987

References

  • Unilateral activation of caudate tyrosine hydroxylase during voluntary circling behavior
    Morgan, Morgan; Yamamoto, Yamamoto; Freed, Freed
  • Striatal dopamine uptake asymmetries and rotational behavior in unlesioned rats: revising the model
    Shapiro, Shapiro; Glick, Glick; Hough, Hough

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