Does spotty calcification attenuate the response of nonculprit plaque to statin therapy?: A serial optical coherence tomography study

Does spotty calcification attenuate the response of nonculprit plaque to statin therapy?: A... INTRODUCTIONCoronary artery calcification (CAC) is a dynamic process that is usually found in the presence of atherosclerotic plaque , and a high correlation exists between arterial calcification and plaque burden . CAC plays an active role in plaque development by its action on macrophage activation, which places patients at higher risk for acute coronary events due to the increment of inflammation . Previous studies detected arterial wall calcium deposits in vivo , and small calcium deposits were more significantly observed in the culprit lesion segment in acute coronary syndrome (ACS) patients using intravascular ultrasound (IVUS) . Kataoka et al. studied atheroma progression in patients with spotty calcification using IVUS and showed that despite the use of medical therapies, spotty calcification was associated with accelerated disease progression and constructive positive modeling . The high resolution of optical coherence tomography (OCT) allows the direct visualization of the plaque microstructure contributing to plaque vulnerability . Recent OCT studies showed that lesions with spotty calcification had thinner fibrous cap thicknesses and demonstrated vulnerable plaque features . In addition, spotty calcification is an independent predictor of plaque rupture in patients with ACS . These findings implied that spotty calcification is a marker of plaque http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Catheterization and Cardiovascular Interventions Wiley

Does spotty calcification attenuate the response of nonculprit plaque to statin therapy?: A serial optical coherence tomography study

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Wiley Periodicals, Inc.
ISSN
1522-1946
eISSN
1522-726X
D.O.I.
10.1002/ccd.27496
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONCoronary artery calcification (CAC) is a dynamic process that is usually found in the presence of atherosclerotic plaque , and a high correlation exists between arterial calcification and plaque burden . CAC plays an active role in plaque development by its action on macrophage activation, which places patients at higher risk for acute coronary events due to the increment of inflammation . Previous studies detected arterial wall calcium deposits in vivo , and small calcium deposits were more significantly observed in the culprit lesion segment in acute coronary syndrome (ACS) patients using intravascular ultrasound (IVUS) . Kataoka et al. studied atheroma progression in patients with spotty calcification using IVUS and showed that despite the use of medical therapies, spotty calcification was associated with accelerated disease progression and constructive positive modeling . The high resolution of optical coherence tomography (OCT) allows the direct visualization of the plaque microstructure contributing to plaque vulnerability . Recent OCT studies showed that lesions with spotty calcification had thinner fibrous cap thicknesses and demonstrated vulnerable plaque features . In addition, spotty calcification is an independent predictor of plaque rupture in patients with ACS . These findings implied that spotty calcification is a marker of plaque

Journal

Catheterization and Cardiovascular InterventionsWiley

Published: Jan 15, 2018

Keywords: ; ; ;

References

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