INTRODUCTIONCoronary artery calcification (CAC) is a dynamic process that is usually found in the presence of atherosclerotic plaque , and a high correlation exists between arterial calcification and plaque burden . CAC plays an active role in plaque development by its action on macrophage activation, which places patients at higher risk for acute coronary events due to the increment of inflammation . Previous studies detected arterial wall calcium deposits in vivo , and small calcium deposits were more significantly observed in the culprit lesion segment in acute coronary syndrome (ACS) patients using intravascular ultrasound (IVUS) . Kataoka et al. studied atheroma progression in patients with spotty calcification using IVUS and showed that despite the use of medical therapies, spotty calcification was associated with accelerated disease progression and constructive positive modeling . The high resolution of optical coherence tomography (OCT) allows the direct visualization of the plaque microstructure contributing to plaque vulnerability . Recent OCT studies showed that lesions with spotty calcification had thinner fibrous cap thicknesses and demonstrated vulnerable plaque features . In addition, spotty calcification is an independent predictor of plaque rupture in patients with ACS . These findings implied that spotty calcification is a marker of plaque
Catheterization and Cardiovascular Interventions – Wiley
Published: Jan 15, 2018
Keywords: ; ; ;
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