Does Hypogonadism Contribute to the Occurrence of a Minimal Trauma Hip Fracture in Elderly Men?

Does Hypogonadism Contribute to the Occurrence of a Minimal Trauma Hip Fracture in Elderly Men? The risk of MTHF in hypogonadal elderly men was investigated with a case‐control model. Cases and controls were selected from males age 65 years and older residing in the 120‐bed McGuire Veterans Affairs Medical Center Nursing Home Care Unit over a 5‐day interval. Historical data and serum free testosterone (fTe) were available on 17 subjects with MTHF and 61 controls. When groups were compared for differences in age, race, alcohol abuse, cigarette abuse, and diseases or drugs that may be associated with MTHF, only race was significantly different. Although 25.6% of residents were black, 100% of MTHF subjects were white (P = 0.004). Hypogonadism was defined as a random fTe <9 pg/mL (normal 9 to 46 pg/mL) and was found in 21 subjects (26.9%). Of cases with a MTHF, 58.8% were hypogonadal compared with only 18.0% of controls. Utilizing logistic regression, a highly significant association was found between hypogonadism and MTHF (P = 0.008), and using the odds ratio, subjects with hypogonadism were 6.5 times more likely to have a MTHF (95% CI 2.0 to 20.6). To adjust for race, the odds ratio was repeated excluding black subjects, and the results remained highly significant (4.6, 95% CI 1.3 to 16.2). We conclude that hypogonadal elderly white men may be at increased risk for MTHF. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of American Geriatrics Society Wiley

Does Hypogonadism Contribute to the Occurrence of a Minimal Trauma Hip Fracture in Elderly Men?

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Publisher
Wiley
Copyright
© The American Geriatrics Society
ISSN
0002-8614
eISSN
1532-5415
DOI
10.1111/j.1532-5415.1991.tb02698.x
Publisher site
See Article on Publisher Site

Abstract

The risk of MTHF in hypogonadal elderly men was investigated with a case‐control model. Cases and controls were selected from males age 65 years and older residing in the 120‐bed McGuire Veterans Affairs Medical Center Nursing Home Care Unit over a 5‐day interval. Historical data and serum free testosterone (fTe) were available on 17 subjects with MTHF and 61 controls. When groups were compared for differences in age, race, alcohol abuse, cigarette abuse, and diseases or drugs that may be associated with MTHF, only race was significantly different. Although 25.6% of residents were black, 100% of MTHF subjects were white (P = 0.004). Hypogonadism was defined as a random fTe <9 pg/mL (normal 9 to 46 pg/mL) and was found in 21 subjects (26.9%). Of cases with a MTHF, 58.8% were hypogonadal compared with only 18.0% of controls. Utilizing logistic regression, a highly significant association was found between hypogonadism and MTHF (P = 0.008), and using the odds ratio, subjects with hypogonadism were 6.5 times more likely to have a MTHF (95% CI 2.0 to 20.6). To adjust for race, the odds ratio was repeated excluding black subjects, and the results remained highly significant (4.6, 95% CI 1.3 to 16.2). We conclude that hypogonadal elderly white men may be at increased risk for MTHF.

Journal

Journal of American Geriatrics SocietyWiley

Published: Aug 1, 1991

References

  • Marked decline in trabecular bone mineral content in healthy men with age: lack of association with sex steroid levels
    Meier, Meier; Orwoll, Orwoll; Keenan, Keenan
  • Race and sex differences in hip fracture incidence
    Farmer, Farmer; White, White; Brody, Brody

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