DNA helicases: Enzymes with essential roles in all aspects of DNA metabolism

DNA helicases: Enzymes with essential roles in all aspects of DNA metabolism DNA helicases catalyze the disruption of the hydrogen bonds that hold the two strands of double‐stranded DNA together. This energy‐requiring unwinding reaction results in the formation of the single‐stranded DNA required as a template or reaction intermediate in DNA replication, repair and recombination. A combination of biochemical and genetic studies have been used to probe and define the roles of the multiple DNA helicases found in E. coli. This work and similar efforts in eukaryotic cells, although far from complete, have established that DNA helicases are essential components of the machinery that interacts with the DNA molecule. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png BioEssays Wiley

DNA helicases: Enzymes with essential roles in all aspects of DNA metabolism

BioEssays, Volume 16 (1) – Jan 1, 1994

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Publisher
Wiley
Copyright
Copyright © 1994 Cambridge University Press
ISSN
0265-9247
eISSN
1521-1878
D.O.I.
10.1002/bies.950160103
Publisher site
See Article on Publisher Site

Abstract

DNA helicases catalyze the disruption of the hydrogen bonds that hold the two strands of double‐stranded DNA together. This energy‐requiring unwinding reaction results in the formation of the single‐stranded DNA required as a template or reaction intermediate in DNA replication, repair and recombination. A combination of biochemical and genetic studies have been used to probe and define the roles of the multiple DNA helicases found in E. coli. This work and similar efforts in eukaryotic cells, although far from complete, have established that DNA helicases are essential components of the machinery that interacts with the DNA molecule.

Journal

BioEssaysWiley

Published: Jan 1, 1994

References

  • D‐E‐A‐D protein family of putative RNA helicases
    Schmid, Schmid; Linder, Linder
  • Prokaryotic DNA replication
    Marians, Marians

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