Distribution of cardiac troponin I in the Japanese general population and factors influencing its concentrations

Distribution of cardiac troponin I in the Japanese general population and factors influencing its... INTRODUCTIONCardiovascular diseases are the second most common cause of death in Japan, and the number of new cases is continuously growing. Among the cardiovascular diseases, one‐third is attributed to ischemic heart diseases including acute myocardial infarction (AMI). For the better management and prognosis of AMI, prompt and accurate diagnosis is crucial.Cardiac troponin I is a protein that is specifically expressed in cardiomyocytes and is eluted in the blood when cardiomyocytes are injured such as by ischemia. Due to its specificity, cardiac troponin I has become one of the most reliable biomarkers for the diagnosis of AMI. In several guidelines including “Third Universal Definition of Myocardial Infarction ” and “2014 AHA/ACC Guideline for the Management of Patients With Non–ST‐elevation Acute Coronary Syndromes,” the 99th percentile cardiac troponin level in the normal population is accepted as the cut‐off for AMI. It is not clear, however, whether the cut‐offs determined in certain areas could be applied to racially and geographically different populations. One high‐sensitivity troponin I (hsTnI) assay (ARCHITECT STAT high‐sensitive troponin I, Abbott Laboratories, Chicago, IL, USA) is one of the most reliable troponin I assays on the Japanese market, which is reported to measure 80%‐90% of the general population. The http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Clinical Laboratory Analysis Wiley

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 Wiley Periodicals, Inc.
ISSN
0887-8013
eISSN
1098-2825
D.O.I.
10.1002/jcla.22294
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONCardiovascular diseases are the second most common cause of death in Japan, and the number of new cases is continuously growing. Among the cardiovascular diseases, one‐third is attributed to ischemic heart diseases including acute myocardial infarction (AMI). For the better management and prognosis of AMI, prompt and accurate diagnosis is crucial.Cardiac troponin I is a protein that is specifically expressed in cardiomyocytes and is eluted in the blood when cardiomyocytes are injured such as by ischemia. Due to its specificity, cardiac troponin I has become one of the most reliable biomarkers for the diagnosis of AMI. In several guidelines including “Third Universal Definition of Myocardial Infarction ” and “2014 AHA/ACC Guideline for the Management of Patients With Non–ST‐elevation Acute Coronary Syndromes,” the 99th percentile cardiac troponin level in the normal population is accepted as the cut‐off for AMI. It is not clear, however, whether the cut‐offs determined in certain areas could be applied to racially and geographically different populations. One high‐sensitivity troponin I (hsTnI) assay (ARCHITECT STAT high‐sensitive troponin I, Abbott Laboratories, Chicago, IL, USA) is one of the most reliable troponin I assays on the Japanese market, which is reported to measure 80%‐90% of the general population. The

Journal

Journal of Clinical Laboratory AnalysisWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

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