Discrimination between descriptive models of L‐glutamate uptake by the retina using non‐linear regression analysis.

Discrimination between descriptive models of L‐glutamate uptake by the retina using... 1. The uptake of labelled L‐glutamate by the isolated rat retina was measured over a large range of external concentrations (1 micron to 1 mM). 2. The results obtained from measurements of the initial velocity of L‐glutamate uptake at different concentrations did not follow simple hyperbolic kinetics. 3. The error structure of replicate velocity measurements was examined and found to be normally distributed and heteroscedastic. 4. Descriptive models were fitted directly to data, weighted by the invariance, using non‐linear regression analysis. 5. The most suitable suitable descriptive model consisted of a saturable hyperbola (Vm = 285 n‐mole.(g wet wt.)‐1.min‐1, Km = 252 micron) and a linear term (b = 0.45 min‐1). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Physiology Wiley

Discrimination between descriptive models of L‐glutamate uptake by the retina using non‐linear regression analysis.

The Journal of Physiology, Volume 277 (1) – Apr 1, 1978

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Publisher
Wiley
Copyright
© 2014 The Physiological Society
ISSN
0022-3751
eISSN
1469-7793
D.O.I.
10.1113/jphysiol.1978.sp012279
Publisher site
See Article on Publisher Site

Abstract

1. The uptake of labelled L‐glutamate by the isolated rat retina was measured over a large range of external concentrations (1 micron to 1 mM). 2. The results obtained from measurements of the initial velocity of L‐glutamate uptake at different concentrations did not follow simple hyperbolic kinetics. 3. The error structure of replicate velocity measurements was examined and found to be normally distributed and heteroscedastic. 4. Descriptive models were fitted directly to data, weighted by the invariance, using non‐linear regression analysis. 5. The most suitable suitable descriptive model consisted of a saturable hyperbola (Vm = 285 n‐mole.(g wet wt.)‐1.min‐1, Km = 252 micron) and a linear term (b = 0.45 min‐1).

Journal

The Journal of PhysiologyWiley

Published: Apr 1, 1978

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