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- Publisher
- Wiley Subscription Services, Inc., A Wiley Company
- Copyright
- Copyright © 2002 International Union of Biochemistry and Molecular Biology
- ISSN
- 1521-6543
- eISSN
- 1521-6551
- DOI
- 10.1080/15216540213823
- pmid
- 12387573
- Publisher site
- See Article on Publisher Site
Abstract
To study the permeability through the cellular membrane of synthetic peptides containing an hydrofobic moiety, we used a 13‐mer myristoylated peptide labeled with a N ‐terminal fluorescent probe. After 2 h of incubation, the subcellular distribution was analyzed in intact chromaffin cells by confocal fluorescent microscopy. Our results demonstrate that myristoylated peptides diffuse into intact cells, showing an heterogeneous distribution, but they do not reach the cellular nucleous, at least during the time range used.
Journal
IUBMB Life – Wiley
Published: Jul 1, 2002
Keywords: Membrane Permeation; Myristoylation; Peptides