Changes in cytosolic free calcium ((Ca2+)i) in the cat cortex were measured in vivo by indo‐1 fluorometry during cerebral ischemia and reperfusion and were correlated to the histopathological ischemic changes. These changes were most pronounced in stroke cases with an increase in (Ca2+)i throughout the ischemic and reperfusion periods. Cases without a (Ca2+)i increase showed no histopathological change in the cortical gyrus in which (Ca2+)i was measured. The data support the hypothesis that an increase in (Ca 2+)i during cerebral ischemia and reperfusion leads to neuronal damage.
Annals of Neurology – Wiley
Published: Aug 1, 1989
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