Direct evidence for calcium‐induced ischemic and reperfusion injury

Direct evidence for calcium‐induced ischemic and reperfusion injury Changes in cytosolic free calcium ((Ca2+)i) in the cat cortex were measured in vivo by indo‐1 fluorometry during cerebral ischemia and reperfusion and were correlated to the histopathological ischemic changes. These changes were most pronounced in stroke cases with an increase in (Ca2+)i throughout the ischemic and reperfusion periods. Cases without a (Ca2+)i increase showed no histopathological change in the cortical gyrus in which (Ca2+)i was measured. The data support the hypothesis that an increase in (Ca 2+)i during cerebral ischemia and reperfusion leads to neuronal damage. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Neurology Wiley

Direct evidence for calcium‐induced ischemic and reperfusion injury

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Publisher
Wiley
Copyright
Copyright © 1989 American Neurological Association
ISSN
0364-5134
eISSN
1531-8249
D.O.I.
10.1002/ana.410260217
Publisher site
See Article on Publisher Site

Abstract

Changes in cytosolic free calcium ((Ca2+)i) in the cat cortex were measured in vivo by indo‐1 fluorometry during cerebral ischemia and reperfusion and were correlated to the histopathological ischemic changes. These changes were most pronounced in stroke cases with an increase in (Ca2+)i throughout the ischemic and reperfusion periods. Cases without a (Ca2+)i increase showed no histopathological change in the cortical gyrus in which (Ca2+)i was measured. The data support the hypothesis that an increase in (Ca 2+)i during cerebral ischemia and reperfusion leads to neuronal damage.

Journal

Annals of NeurologyWiley

Published: Aug 1, 1989

References

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