Dimethylheptyl‐THC‐11 OIC acid: A nonpsychoactive antiinflammatory agent with a cannabinoid template structure

Dimethylheptyl‐THC‐11 OIC acid: A nonpsychoactive antiinflammatory agent with a cannabinoid... Objective To assess the antiinflammatory activity of dimethylheptyl‐THC‐11 oic acid (DMH‐11C), a nonpsychoactive synthetic derivative of tetrahydrocannabinol. Methods Acute inflammation was induced by injection of interleukin‐1β and tumor necrosis factor α into subcutaneous air pouches formed on the backs of mice. Inflammation was quantified 6 hours later by pouch fluid leukocyte counts. Adjuvant‐induced polyarthritis in rats was used as a model of chronic inflammation and joint tissue injury. Animals were either untreated, treated with safflower oil, or treated with DMH‐11C in safflower oil. Arthritis was assessed by clinical observation and by histomorphologic evaluation of tibiotarsal joints. Results Oral administration of DMH‐11C reduced the accumulation of pouch fluid leukocytes and significantly reduced the severity of adjuvant‐induced polyarthritis. Histopathologic studies of tibiotarsal joints showed that DMH‐11C treatment attenuated pannus formation and joint tissue injury. Conclusion DMH‐11C suppresses acute inflammation in the subcutaneous air pouch in mice and chronic joint inflammation characteristic of adjuvant disease in rats. These results demonstrate the potential use of this nonpsychoactive cannabinoid as an antiinflammatory agent. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Arthritis & Rheumatology Wiley

Dimethylheptyl‐THC‐11 OIC acid: A nonpsychoactive antiinflammatory agent with a cannabinoid template structure

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Publisher
Wiley
Copyright
Copyright © 1998 by the American College of Rheumatology
ISSN
0004-3591
eISSN
1529-0131
D.O.I.
10.1002/1529-0131(199801)41:1<163::AID-ART20>3.0.CO;2-9
Publisher site
See Article on Publisher Site

Abstract

Objective To assess the antiinflammatory activity of dimethylheptyl‐THC‐11 oic acid (DMH‐11C), a nonpsychoactive synthetic derivative of tetrahydrocannabinol. Methods Acute inflammation was induced by injection of interleukin‐1β and tumor necrosis factor α into subcutaneous air pouches formed on the backs of mice. Inflammation was quantified 6 hours later by pouch fluid leukocyte counts. Adjuvant‐induced polyarthritis in rats was used as a model of chronic inflammation and joint tissue injury. Animals were either untreated, treated with safflower oil, or treated with DMH‐11C in safflower oil. Arthritis was assessed by clinical observation and by histomorphologic evaluation of tibiotarsal joints. Results Oral administration of DMH‐11C reduced the accumulation of pouch fluid leukocytes and significantly reduced the severity of adjuvant‐induced polyarthritis. Histopathologic studies of tibiotarsal joints showed that DMH‐11C treatment attenuated pannus formation and joint tissue injury. Conclusion DMH‐11C suppresses acute inflammation in the subcutaneous air pouch in mice and chronic joint inflammation characteristic of adjuvant disease in rats. These results demonstrate the potential use of this nonpsychoactive cannabinoid as an antiinflammatory agent.

Journal

Arthritis & RheumatologyWiley

Published: Jan 1, 1998

References

  • The formation of a structure with the features of synovial lining by subcutaneous injections of air: an in vivo tissue culture system
    Edwards, Edwards; Sedgwick, Sedgwick; Willoughby, Willoughby
  • Joint destruction in arthritis: metalloproteinases in the spotlight
    Brinckerhoff, Brinckerhoff
  • Proinflammatory cytokines regulate cyclooxygenase‐2 mRNA expression in human macrophages
    Arias‐Negrete, Arias‐Negrete; Keller, Keller; Chandee, Chandee

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