Dihydroartemisinin up‐regulates VE‐cadherin expression in human renal glomerular endothelial cells

Dihydroartemisinin up‐regulates VE‐cadherin expression in human renal glomerular endothelial... The antimalarial agent dihydroartemisinin (DHA) has been shown to be anti‐inflammatory. In this study, we found that DHA increased the expression of the junctional protein vascular endothelial (VE)‐cadherin in human renal glomerular endothelial cells. In addition, DHA inhibited TGF‐β RI‐Smad2/3 signalling and its downstream effectors SNAIL and SLUG, which repress VE‐cadherin gene transcription. Correspondingly, DHA decreased the binding of SNAIL and SLUG to the VE‐cadherin promoter. Together, our results suggest an effect of DHA in regulating glomerular permeability by elevation of VE‐cadherin expression. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Cellular and Molecular Medicine Wiley

Dihydroartemisinin up‐regulates VE‐cadherin expression in human renal glomerular endothelial cells

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Publisher
Wiley
Copyright
Copyright © 2018 John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine
ISSN
1582-1838
eISSN
1582-4934
D.O.I.
10.1111/jcmm.13448
Publisher site
See Article on Publisher Site

Abstract

The antimalarial agent dihydroartemisinin (DHA) has been shown to be anti‐inflammatory. In this study, we found that DHA increased the expression of the junctional protein vascular endothelial (VE)‐cadherin in human renal glomerular endothelial cells. In addition, DHA inhibited TGF‐β RI‐Smad2/3 signalling and its downstream effectors SNAIL and SLUG, which repress VE‐cadherin gene transcription. Correspondingly, DHA decreased the binding of SNAIL and SLUG to the VE‐cadherin promoter. Together, our results suggest an effect of DHA in regulating glomerular permeability by elevation of VE‐cadherin expression.

Journal

Journal of Cellular and Molecular MedicineWiley

Published: Jan 1, 2018

Keywords: ; ; ;

References

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