INTRODUCTIONThe differential diagnosis of hereditary hemolytic anemia is often complicated and time‐consuming. It requires advanced laboratory tests, such as hemoglobin characterization by high‐performance liquid chromatography (HPLC), osmotic fragility tests, osmotic gradient ektacytometry, EMA‐binding test, and activity measurements of multiple red cell enzymes. In addition, genetic tests are regularly needed to confirm a suspected disorder, which increases financial burdens for hospital budgets and healthcare insurance companies. One of the first steps in the differential diagnosis of hemolytic anemia is a careful microscopic examination of the morphological appearance of the red blood cell (RBC). Manual morphology analysis, however, is time‐consuming, expensive and always subjected to some level of subjectivity. Manual morphology is also hampered by a lack of standardization, although attempts to standardize the nomenclature and grading system of peripheral blood smears is an important step forward. A relatively inexpensive and high‐throughput gatekeeper that gives direction for further diagnostic testing would therefore strongly increase the diagnostic efficiency in the field of hereditary hemolytic anemia.Digital microscopy (DM) is a relatively new technique that automatically classifies the cells using the accompanying software. DM has first been validated for leukocyte differentiation, and good correlations between automated and manual examinations of peripheral blood smears were
International Journal of Laboratory Hematology – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ;
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.
All for just $49/month
Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.
Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.
It’s easy to organize your research with our built-in tools.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera