Diffuse cerebral ischemia in the cat: III. Neuropathological sequelae of severe ischemia

Diffuse cerebral ischemia in the cat: III. Neuropathological sequelae of severe ischemia The neuropathological consequences of severe diffuse cerebral ischemia were investigated in an animal model in which postischemic alterations of regional brain blood flow and energy metabolism had been previously characterized. Pentobarbital‐aneshetized cats received either 15 or 30 minutes of ischemia produced by basilar artery and bilateral carotid artery occlusions plus mild hypotension; this was followed by 60 to 90 minutes of normotensive recirculation. The brains were perfusion‐fixed for light microscopy. Both insult durations resulted in unequivocal ischemic cell change affecting neurons of the cerebral neocortex, striatum, thalamus, and hippocampus and portions of the rostral brainstem. Animals with 30 minutes of prior ischemia differed from those with 15 minutes of ischemia in showing a more apparent regional accentuation of ischemic change in the parasagittal cortical gyri—the sites of previously documented focal postischemic heterogeneities of blood flow and metabolism. In other respects, however, the overall distribution and spectrum of severity of the ischemic alterations were similar for the two insult durations. These data support the view that significant permanent neuronal injury may result from a period of cerebral ischemia as brief as 15 minutes. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Neurology Wiley

Diffuse cerebral ischemia in the cat: III. Neuropathological sequelae of severe ischemia

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Publisher
Wiley
Copyright
Copyright © 1979 American Neurological Association
ISSN
0364-5134
eISSN
1531-8249
DOI
10.1002/ana.410050408
Publisher site
See Article on Publisher Site

Abstract

The neuropathological consequences of severe diffuse cerebral ischemia were investigated in an animal model in which postischemic alterations of regional brain blood flow and energy metabolism had been previously characterized. Pentobarbital‐aneshetized cats received either 15 or 30 minutes of ischemia produced by basilar artery and bilateral carotid artery occlusions plus mild hypotension; this was followed by 60 to 90 minutes of normotensive recirculation. The brains were perfusion‐fixed for light microscopy. Both insult durations resulted in unequivocal ischemic cell change affecting neurons of the cerebral neocortex, striatum, thalamus, and hippocampus and portions of the rostral brainstem. Animals with 30 minutes of prior ischemia differed from those with 15 minutes of ischemia in showing a more apparent regional accentuation of ischemic change in the parasagittal cortical gyri—the sites of previously documented focal postischemic heterogeneities of blood flow and metabolism. In other respects, however, the overall distribution and spectrum of severity of the ischemic alterations were similar for the two insult durations. These data support the view that significant permanent neuronal injury may result from a period of cerebral ischemia as brief as 15 minutes.

Journal

Annals of NeurologyWiley

Published: Apr 1, 1979

References

  • Diffuse cerebral ischemia in the cat: I. Local blood flow during severe ischemia and recirculation
    Ginsberg, Ginsberg; Budd, Budd; Welsh, Welsh
  • Cerebral energy metabolism during transient ischemia and recovery in the gerbil
    Levy, Levy; Duffy, Duffy
  • Diffuse cerebral ischemia in the cat. II. Regional metabolites during severe ischemia and recirculation
    Welsh, Welsh; Ginsberg, Ginsberg; Rieder, Rieder

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