Diffuse axonal injury due to nonmissile head injury in humans: An analysis of 45 cases

Diffuse axonal injury due to nonmissile head injury in humans: An analysis of 45 cases Forty‐five cases of diffuse axonal injury (DAI) brought about by nonmissile head injury in humans are analyzed and compared with 132 cases of fatal head injury without DAI. All cases were subjected to a comprehensive neuropathological study. In the patients with DAI a statistically significant lower incidence of lucid interval, fracture of the skull, cerebral contusions, intracranial hematoma, and evidence of high intracranial pressure were found, with a higher incidence of head injury due to road traffic accident. Brain swelling and hypoxic brain damage were not statistically different in the two groups. The features of DAI in humans are compared with the DAI that has been produced in subhuman primates by pure inertial loading brought about by angular acceleration of the head. The available evidence indicates that DAI in human beings occurs at the time of head injury and is not due to complicating factors such as hypoxia, brain swelling, or raised intracranial pressure. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Neurology Wiley

Diffuse axonal injury due to nonmissile head injury in humans: An analysis of 45 cases

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Publisher
Wiley
Copyright
Copyright © 1982 American Neurological Association
ISSN
0364-5134
eISSN
1531-8249
DOI
10.1002/ana.410120610
Publisher site
See Article on Publisher Site

Abstract

Forty‐five cases of diffuse axonal injury (DAI) brought about by nonmissile head injury in humans are analyzed and compared with 132 cases of fatal head injury without DAI. All cases were subjected to a comprehensive neuropathological study. In the patients with DAI a statistically significant lower incidence of lucid interval, fracture of the skull, cerebral contusions, intracranial hematoma, and evidence of high intracranial pressure were found, with a higher incidence of head injury due to road traffic accident. Brain swelling and hypoxic brain damage were not statistically different in the two groups. The features of DAI in humans are compared with the DAI that has been produced in subhuman primates by pure inertial loading brought about by angular acceleration of the head. The available evidence indicates that DAI in human beings occurs at the time of head injury and is not due to complicating factors such as hypoxia, brain swelling, or raised intracranial pressure.

Journal

Annals of NeurologyWiley

Published: Dec 1, 1982

References

  • The relationship between ventricular fluid pressure and the neuropathology of raised intracranial pressure
    Adams, Adams; Graham, Graham
  • The contusion index: a quantitative approach to cerebral contusions in head injury
    Adams, Adams; Scott, Scott; Parker, Parker; Graham, Graham; Doyle, Doyle
  • Diffuse axonal injury and traumatic coma in the primate
    Gennarelli, Gennarelli; Thibault, Thibault; Adams, Adams; Graham, Graham; Thompson, Thompson; Marcincin, Marcincin

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