IntroductionGerm cell development is the fundamental procedure for species’ existence. In mammals, the fertilization of female and male germ cells enables a new life cycle. Starting from the fertilized zygote, several round of cell‐division results in the formation of inner cell mass (ICM) and trophectoderm. The cells in the ICM are pluripotent. Accompanied by embryo development, some of the cells in ICM develops into epiblast cells (Surani et al., ; Rossant, ). Responding to the bone morphogenetic protein 4 (BMP4) produced by the extra‐embryonic ectoderm (ExE), a small number of cells at the proximal epiblasts begin to express Fragilis/Ifitm3 (Saitou et al., ; Tanaka and Matsui, ). At embryonic day 6.25 (E6.25), Blimp1/Prdm1 starts to be expressed in a few Fragilis‐positive cells that come into direct contact with the ExE, and this marks the appearance of the PGC precursor cells (Tam and Zhou, ; Ohinata et al., ; Hayashi et al., ; Hayashi et al., ). With the persistent induction of surrounding signals, the number of the Blimp1‐positive cells increases along with the expression of Prdm14 and Dppa3 specifying the PGCs at the onset of gastrulation (Bortvin et al., ; McLaren and Lawson, ; Kurimoto et al., ; Yamaji
Cell Biology International – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ; ;
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