Differential increases in chromogranins, but not synapsin I, in cortical neurons following spreading depression: implications for functional roles and transmitter peptide release

Differential increases in chromogranins, but not synapsin I, in cortical neurons following... Experimental damage of cerebral cortex induces a slow‐moving depolarization and subsequent depression of activity called cortical spreading depression (CSD) which is associated with various ionic, metabolic and genomic changes. Chromogranins are a family of water‐soluble acidic proteins with a widespread distribution in secretory, large dense‐core vesicles of neurons. We have earlier reported that secretogranin II (SgII) mRNA is increased in cerebral cortex hours after a unilateral craniotomy which would have induced CSD. To investigate further the regulation of chromogranin systems and the nature of genomic and biochemical changes produced by CSD, this study examined the temporal changes in chromogranin A (CgA), chromogranin B (CgB) and SgII mRNAs and CgB and SgII immunoreactivity (IR) in cerebral cortex and hippocampus following unilateral http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Neuroscience Wiley

Differential increases in chromogranins, but not synapsin I, in cortical neurons following spreading depression: implications for functional roles and transmitter peptide release

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Abstract

Experimental damage of cerebral cortex induces a slow‐moving depolarization and subsequent depression of activity called cortical spreading depression (CSD) which is associated with various ionic, metabolic and genomic changes. Chromogranins are a family of water‐soluble acidic proteins with a widespread distribution in secretory, large dense‐core vesicles of neurons. We have earlier reported that secretogranin II (SgII) mRNA is increased in cerebral cortex hours after a unilateral craniotomy which would have induced CSD. To investigate further the regulation of chromogranin systems and the nature of genomic and biochemical changes produced by CSD, this study examined the temporal changes in chromogranin A (CgA), chromogranin B (CgB) and SgII mRNAs and CgB and SgII immunoreactivity (IR) in cerebral cortex and hippocampus following unilateral

Journal

European Journal of NeuroscienceWiley

Published: Jan 1, 1998

References

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  • Distribution of mRNAs for chromogranins A and B and secretogranin II in rat brain
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  • The 5′‐flanking region of the synapsin I gene. A G+C‐rich, TATA‐ and CAAT‐less, phylogenetically conserved sequence with cell type‐specific promoter function
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