Differential Effects of Long‐Term Electroconvulsive Shock on Brain Levels of Enkephalin and Humoral‐Endorphin

Differential Effects of Long‐Term Electroconvulsive Shock on Brain Levels of Enkephalin and... Abstract: Electroconvulsive shock (ECS) administrations repeated for 10 consecutive days cause an elevation in the opioid content of the rat brain. Two different endogenous opioids, enkephalin and humoral‐endorphin, undergo independent changes that differ in both their time course and intracerebral localization. These metabolic changes parallel long‐term behavioral modifications such as the development and dissipation of tolerance to the analgesic effect of ECS. The activation of two different, independent, endogenous opioid systems by ECS is in agreement with previous behavioral and pharmacological studies. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neurochemistry Wiley

Differential Effects of Long‐Term Electroconvulsive Shock on Brain Levels of Enkephalin and Humoral‐Endorphin

Journal of Neurochemistry, Volume 39 (5) – Nov 1, 1982

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Publisher
Wiley
Copyright
Copyright © 1982 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0022-3042
eISSN
1471-4159
DOI
10.1111/j.1471-4159.1982.tb12594.x
Publisher site
See Article on Publisher Site

Abstract

Abstract: Electroconvulsive shock (ECS) administrations repeated for 10 consecutive days cause an elevation in the opioid content of the rat brain. Two different endogenous opioids, enkephalin and humoral‐endorphin, undergo independent changes that differ in both their time course and intracerebral localization. These metabolic changes parallel long‐term behavioral modifications such as the development and dissipation of tolerance to the analgesic effect of ECS. The activation of two different, independent, endogenous opioid systems by ECS is in agreement with previous behavioral and pharmacological studies.

Journal

Journal of NeurochemistryWiley

Published: Nov 1, 1982

References

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