Differential effect of MK 801 and scopolamine on c‐fos expression induced by L‐dopa in the striatum of 6‐hydroxydopamine lesioned rats

Differential effect of MK 801 and scopolamine on c‐fos expression induced by L‐dopa in the... In rats with a unilateral 6‐hydroxydopamine lesion of the dopaminergic nigro‐striatal pathway, striatal Dl‐receptor‐stimulated c‐fos expression and turning behavior are positively modulated by D2 receptor stimulation and by blockade of N‐methyl‐D‐aspartate (NMDA) or muscarinic receptors. Combined D1/D2 receptor stimulation by L‐dopa activates c‐fos in a manner not additive with muscarinic receptor blockade by scopolamine. On the other hand, blockade of NMDA receptors by MK 801 reduced c‐fos expression induced by L‐dopa while, depending on the dose of L‐dopa, differentially affecting contralateral turning behavior. The results are interpreted to suggest that D2 receptor stimulation amplifies D1‐receptor‐mediated c‐fos expression by two mechanisms differentially related to muscarinic and NMDA receptors. ©1994 Wilev‐Lisa. Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Synapse Wiley

Differential effect of MK 801 and scopolamine on c‐fos expression induced by L‐dopa in the striatum of 6‐hydroxydopamine lesioned rats

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Publisher
Wiley
Copyright
Copyright © 1994 Wiley‐Liss, Inc.
ISSN
0887-4476
eISSN
1098-2396
DOI
10.1002/syn.890180403
Publisher site
See Article on Publisher Site

Abstract

In rats with a unilateral 6‐hydroxydopamine lesion of the dopaminergic nigro‐striatal pathway, striatal Dl‐receptor‐stimulated c‐fos expression and turning behavior are positively modulated by D2 receptor stimulation and by blockade of N‐methyl‐D‐aspartate (NMDA) or muscarinic receptors. Combined D1/D2 receptor stimulation by L‐dopa activates c‐fos in a manner not additive with muscarinic receptor blockade by scopolamine. On the other hand, blockade of NMDA receptors by MK 801 reduced c‐fos expression induced by L‐dopa while, depending on the dose of L‐dopa, differentially affecting contralateral turning behavior. The results are interpreted to suggest that D2 receptor stimulation amplifies D1‐receptor‐mediated c‐fos expression by two mechanisms differentially related to muscarinic and NMDA receptors. ©1994 Wilev‐Lisa. Inc.

Journal

SynapseWiley

Published: Dec 1, 1994

References

  • The functional anatomy of basal ganglia disorders
    Albin, Albin; Young, Young; Penny, Penny
  • Dopamine and glutamate agonists stimulate neuron specific expression of fos‐like protein in the striatum
    Beretta, Beretta; Robertson, Robertson; Graybiel, Graybiel
  • Fos immunoreactivity after stimulation or inhibition of muscarinic receptors indicates anatomical specificity for cholinergic control of striatal efferent neurons and cortical neurons in the rat
    Bernard, Bernard; Dumartin, Dumartin; Lamy, Lamy; Bloch, Bloch

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