Differential anatomical location of ( 3 H)‐N, n ‐propylnorapomorphine and ( 3 H)‐spiperone binding sites in the striatum and substantia nigra of the rat

Differential anatomical location of ( 3 H)‐N, n ‐propylnorapomorphine and ( 3 H)‐spiperone... 1 Specific (3H)‐spiperone and (3H)‐N,n‐propylnorapomorphine (NPA) binding was measured in striatum and substantia nigra of the rat following unilateral 6‐hydroxydopamine (6‐OHDA) lesions of the medial forebrain bundle, kainic acid lesions of the substantia nigra or striatum, and following decortication. 2 Binding sites labelled by (3H)‐spiperone in striatum were found to lie on striatal cell bodies and on the terminals of cortico‐striate glutamate fibres, but not on presynaptic dopamine terminals. In contrast, binding sites labelled by (3H)‐NPA were demonstrated on striatal cell bodies and on the terminals of nigro‐striatal dopamine fibres, but not on cortical afferents. 3 In substantia nigra, specific (3H)‐spiperone binding sites were found only on non‐dopamine cell bodies. No clear evidence was found for their existence on dopamine cell bodies, the terminals of strio‐nigral fibres or the terminals of cortico‐nigral fibres. In contrast, specific binding sites for (3H)‐NPA were found on dopamine cell bodies and the terminals of strio‐nigral fibres. Localization on non‐dopamine cell bodies or on cortico‐nigral fibres was not demonstrated. 4 These studies support the concept of differential localization of agonist and antagonist binding sites. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Pharmacology Wiley

Differential anatomical location of ( 3 H)‐N, n ‐propylnorapomorphine and ( 3 H)‐spiperone binding sites in the striatum and substantia nigra of the rat

Loading next page...
 
/lp/wiley/differential-anatomical-location-of-3-h-n-n-propylnorapomorphine-and-3-SHxZPAvaYn
Publisher
Wiley
Copyright
1983 British Pharmacological Society
ISSN
0007-1188
eISSN
1476-5381
D.O.I.
10.1111/j.1476-5381.1983.tb11035.x
Publisher site
See Article on Publisher Site

Abstract

1 Specific (3H)‐spiperone and (3H)‐N,n‐propylnorapomorphine (NPA) binding was measured in striatum and substantia nigra of the rat following unilateral 6‐hydroxydopamine (6‐OHDA) lesions of the medial forebrain bundle, kainic acid lesions of the substantia nigra or striatum, and following decortication. 2 Binding sites labelled by (3H)‐spiperone in striatum were found to lie on striatal cell bodies and on the terminals of cortico‐striate glutamate fibres, but not on presynaptic dopamine terminals. In contrast, binding sites labelled by (3H)‐NPA were demonstrated on striatal cell bodies and on the terminals of nigro‐striatal dopamine fibres, but not on cortical afferents. 3 In substantia nigra, specific (3H)‐spiperone binding sites were found only on non‐dopamine cell bodies. No clear evidence was found for their existence on dopamine cell bodies, the terminals of strio‐nigral fibres or the terminals of cortico‐nigral fibres. In contrast, specific binding sites for (3H)‐NPA were found on dopamine cell bodies and the terminals of strio‐nigral fibres. Localization on non‐dopamine cell bodies or on cortico‐nigral fibres was not demonstrated. 4 These studies support the concept of differential localization of agonist and antagonist binding sites.

Journal

British Journal of PharmacologyWiley

Published: Jun 1, 1983

References

  • Synaptic mechanisms in the substantia nigra
    DRAY, DRAY; STRAUGHAN, STRAUGHAN
  • Multiple receptors for dopamine
    KEBABIAN, KEBABIAN; CALNE, CALNE
  • Localization of dopamine receptors in rat brain
    REISINE, REISINE; NAGY, NAGY; FIBIGER, FIBIGER; YAMAMURA, YAMAMURA
  • Stimulatory effect of L‐glutamate and related amino acids on ( 3 H)‐dopamine release from rat striatum: an in vitro model for glutamate actions
    ROBERTS, ROBERTS; ANDERSON, ANDERSON

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off