IntroductionPrevious research has suggested that erosive esophagitis (EE) is a multifactorial process involving an imbalance between aggressive and defensive factors. After acid reflux, clearance of acid from the esophagus is an important defense mechanism against the development of EE. Esophageal clearance of regurgitated gastric contents occurs by three mechanisms: gravity, propulsive peristalsis, and salivary secretion. In particular, salivation promotes esophageal acid clearance not only by eliciting swallowing but also by enhancing washout, dilution, and neutralization of the acid.Recent studies have revealed that up to 70% of patients with gastroesophageal reflux disease (GERD) have nonerosive reflux disease (NERD). However, few reports have addressed the functional differences in salivary secretion between NERD and EE. Although the mechanism of salivary secretion is complex, some of its aspects are considered to be under autonomic nervous system control. Parasympathetic stimulation elicits both secretory and vasodilator responses in the cat submandibular gland. Some parasympathetically induced secretions are affected by fluctuations of the arterial blood flow in the dog submandibular gland. It is important to investigate the relationship between salivary secretion and the arterial blood flow in humans. However, this has not yet been performed, in part because of the lack of a convenient and objective
Journal of Gastroenterology and Hepatology – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ;
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