Differences in innervated neurons of the internal anal sphincter based on age and sex: A histological study

Differences in innervated neurons of the internal anal sphincter based on age and sex: A... IntroductionFecal incontinence is a relatively common anorectal disorder, with an incidence ranging from 11 to 15% according to research of a community‐based sample of adults. Many reports have shown that age is a risk factor for fecal incontinence. The incidence of fecal incontinence based on sex is controversial. Some reports have stated that there is no difference in fecal incontinence between men and women. In contrast, other reports have suggested that fecal incontinence is more common in women than in men. However, examination of anal function using manometry has shown a difference in fecal incontinence associated with age, as well as sex. Some morphological changes, such as tearing of muscle fibers during childbirth and an increase in thickness of the anal sphincter muscle as a result of aging, might explain differences in anal function.In recent years, introduction of sacral nerve stimulation, a novel treatment method for fecal incontinence, has drawn attention to the underlying neuronal pathology of fecal incontinence. As shown by the efficacy of neural mediation, anal sphincter hypofunction appears to be caused by changes not only in the muscle tissue, but also in the neurons controlling the anal sphincter. Several reports have shown that the amount of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Geriatrics & Gerontology International Wiley

Differences in innervated neurons of the internal anal sphincter based on age and sex: A histological study

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Publisher
Wiley
Copyright
© 2018 Japan Geriatrics Society
ISSN
1444-1586
eISSN
1447-0594
D.O.I.
10.1111/ggi.13193
Publisher site
See Article on Publisher Site

Abstract

IntroductionFecal incontinence is a relatively common anorectal disorder, with an incidence ranging from 11 to 15% according to research of a community‐based sample of adults. Many reports have shown that age is a risk factor for fecal incontinence. The incidence of fecal incontinence based on sex is controversial. Some reports have stated that there is no difference in fecal incontinence between men and women. In contrast, other reports have suggested that fecal incontinence is more common in women than in men. However, examination of anal function using manometry has shown a difference in fecal incontinence associated with age, as well as sex. Some morphological changes, such as tearing of muscle fibers during childbirth and an increase in thickness of the anal sphincter muscle as a result of aging, might explain differences in anal function.In recent years, introduction of sacral nerve stimulation, a novel treatment method for fecal incontinence, has drawn attention to the underlying neuronal pathology of fecal incontinence. As shown by the efficacy of neural mediation, anal sphincter hypofunction appears to be caused by changes not only in the muscle tissue, but also in the neurons controlling the anal sphincter. Several reports have shown that the amount of

Journal

Geriatrics & Gerontology InternationalWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

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