A59 (P87) Carrying more ‘favourable adiposity’ genetic factors is associated with higher adiposity but lower ectopic fat and lower risk of Type 2 diabetesH YAGHOOTKAR1, Y Ji1, AM Yiorkas2,3, J Tyrrell1, SE Jones1, R Beaumont1, AR Wood1, AIF Blakemore2,3, JD Bell4 and TM Frayling11Genetics of Human Complex Traits, University of Exeter Medical School, Exeter, UK, 2Section of Investigative Medicine, Imperial College London, London, UK, 3Department of Life Sciences, Brunel University London, Uxbridge, UK, 4Research Centre for Optimal Health, University of Westminster, London, UKAims: There are obese individuals who can live without Type 2 diabetes throughout their lives. Genetic studies have found genetic variants where the allele associated with higher adiposity is associated with lower risk of Type 2 diabetes. We took a novel approach to find more of these genetic variants to understand the underlying mechanisms.Methods: We used 451,000 individuals from UK Biobank to find genetic variants associated with body fat percentage as a measure of adiposity. We then used data from published genome‐wide association studies (GWASs) in a multivariate test to find ‘favourable adiposity’ alleles associated with higher adiposity but a ‘favourable’ metabolic phenotype: higher HDL‐C, adiponectin, sex hormone binding globulin, but lower triglycerides, fasting insulin and alanine transaminase.Results:
Diabetic Medicine – Wiley
Published: Jan 1, 2018
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