Diabetes risk factors and complications

Diabetes risk factors and complications A59 (P87) Carrying more ‘favourable adiposity’ genetic factors is associated with higher adiposity but lower ectopic fat and lower risk of Type 2 diabetesH YAGHOOTKAR1, Y Ji1, AM Yiorkas2,3, J Tyrrell1, SE Jones1, R Beaumont1, AR Wood1, AIF Blakemore2,3, JD Bell4 and TM Frayling11Genetics of Human Complex Traits, University of Exeter Medical School, Exeter, UK, 2Section of Investigative Medicine, Imperial College London, London, UK, 3Department of Life Sciences, Brunel University London, Uxbridge, UK, 4Research Centre for Optimal Health, University of Westminster, London, UKAims: There are obese individuals who can live without Type 2 diabetes throughout their lives. Genetic studies have found genetic variants where the allele associated with higher adiposity is associated with lower risk of Type 2 diabetes. We took a novel approach to find more of these genetic variants to understand the underlying mechanisms.Methods: We used 451,000 individuals from UK Biobank to find genetic variants associated with body fat percentage as a measure of adiposity. We then used data from published genome‐wide association studies (GWASs) in a multivariate test to find ‘favourable adiposity’ alleles associated with higher adiposity but a ‘favourable’ metabolic phenotype: higher HDL‐C, adiponectin, sex hormone binding globulin, but lower triglycerides, fasting insulin and alanine transaminase.Results: http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Diabetic Medicine Wiley

Diabetes risk factors and complications

Loading next page...
 
/lp/wiley/diabetes-risk-factors-and-complications-TidLr0gkv0
Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Diabetic Medicine © 2018 Diabetes UK
ISSN
0742-3071
eISSN
1464-5491
D.O.I.
10.1111/dme.11_13570
Publisher site
See Article on Publisher Site

Abstract

A59 (P87) Carrying more ‘favourable adiposity’ genetic factors is associated with higher adiposity but lower ectopic fat and lower risk of Type 2 diabetesH YAGHOOTKAR1, Y Ji1, AM Yiorkas2,3, J Tyrrell1, SE Jones1, R Beaumont1, AR Wood1, AIF Blakemore2,3, JD Bell4 and TM Frayling11Genetics of Human Complex Traits, University of Exeter Medical School, Exeter, UK, 2Section of Investigative Medicine, Imperial College London, London, UK, 3Department of Life Sciences, Brunel University London, Uxbridge, UK, 4Research Centre for Optimal Health, University of Westminster, London, UKAims: There are obese individuals who can live without Type 2 diabetes throughout their lives. Genetic studies have found genetic variants where the allele associated with higher adiposity is associated with lower risk of Type 2 diabetes. We took a novel approach to find more of these genetic variants to understand the underlying mechanisms.Methods: We used 451,000 individuals from UK Biobank to find genetic variants associated with body fat percentage as a measure of adiposity. We then used data from published genome‐wide association studies (GWASs) in a multivariate test to find ‘favourable adiposity’ alleles associated with higher adiposity but a ‘favourable’ metabolic phenotype: higher HDL‐C, adiponectin, sex hormone binding globulin, but lower triglycerides, fasting insulin and alanine transaminase.Results:

Journal

Diabetic MedicineWiley

Published: Jan 1, 2018

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off