Developmental dyslexia in women: Neuropathological findings in three patients

Developmental dyslexia in women: Neuropathological findings in three patients Brains from male cases with dyslexia show symmetry of the planum temporale and predominantly left‐sided cerebrocortical microdysgenesis. We now report on three women with dyslexia. In all brains, the planum temporale was again symmetrical. Also, in two of the brains, multiple foci of cerebrocortical glial scarring were present. In both women, many of the scars were myelinated, suggesting origination during late intrauterine or early postnatal life. In one, scars were mainly left perisylvian and involved portions of the vascular border zone of the temporal cortex. In the other, scars were more numerous and occurred in the border zone of the anterior, middle, and posterior cerebral arteries symmetrically. All three cases showed to a variable extent brain warts, molecular layer ectopias, and focal architectonic dysplasia identical to those seen in the male cases. Two women had primary brain neoplasms, an oligodendroglioma and a low‐grade astrocytoma, respectively, and two women showed small angiomas. Reexamination of previously reported male cases disclosed one with myelinated glial scars. Two control brains with asymmetrical plana temporale showed myelinated glial scars as well. The significance of the anatomical findings is discussed, and possible etiological factors are considered with known effects of autoimmune diseases on the nervous system. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Neurology Wiley

Developmental dyslexia in women: Neuropathological findings in three patients

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Publisher
Wiley
Copyright
Copyright © 1990 American Neurological Association
ISSN
0364-5134
eISSN
1531-8249
DOI
10.1002/ana.410280602
pmid
2285260
Publisher site
See Article on Publisher Site

Abstract

Brains from male cases with dyslexia show symmetry of the planum temporale and predominantly left‐sided cerebrocortical microdysgenesis. We now report on three women with dyslexia. In all brains, the planum temporale was again symmetrical. Also, in two of the brains, multiple foci of cerebrocortical glial scarring were present. In both women, many of the scars were myelinated, suggesting origination during late intrauterine or early postnatal life. In one, scars were mainly left perisylvian and involved portions of the vascular border zone of the temporal cortex. In the other, scars were more numerous and occurred in the border zone of the anterior, middle, and posterior cerebral arteries symmetrically. All three cases showed to a variable extent brain warts, molecular layer ectopias, and focal architectonic dysplasia identical to those seen in the male cases. Two women had primary brain neoplasms, an oligodendroglioma and a low‐grade astrocytoma, respectively, and two women showed small angiomas. Reexamination of previously reported male cases disclosed one with myelinated glial scars. Two control brains with asymmetrical plana temporale showed myelinated glial scars as well. The significance of the anatomical findings is discussed, and possible etiological factors are considered with known effects of autoimmune diseases on the nervous system.

Journal

Annals of NeurologyWiley

Published: Dec 1, 1990

References

  • Cytoarchitectonic abnormalities in developmental dyslexia: a case study
    Galaburda, Galaburda; Kemper, Kemper
  • Developmental dyslexia: four consecutive patients with cortical anomalies
    Galaburda, Galaburda; Sherman, Sherman; Rosen, Rosen
  • Neurotransmitter alterations in a model of perinatal hypoxic‐ischemic brain injury
    Johnston, Johnston
  • Neurological complications of vasculitis
    Moore, Moore
  • Neurological disease associated with antiphospholipid antibodies
    Briley, Briley; Coull, Coull; Goodnight, Goodnight
  • Neonatal lupus risk to newborns of mothers with systemic lupus erythematosus
    Lockshin, Lockshin; Bonfa, Bonfa; Elkon, Elkon; Druzin, Druzin

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