Developmental Disruption of Thyroid Hormone: Correlations with Hearing Dysfunction in Rats

Developmental Disruption of Thyroid Hormone: Correlations with Hearing Dysfunction in Rats A wide variety of environmental contaminants adversely affect thyroid hormone (TH) homeostasis. Hypothyroidism and/or hypothyroxinemia during the early postnatal period in the rat leads to permanent structural damage and loss of function in the cochlea. A major uncertainty in assessing the risks of developmental exposure to thyroid‐disrupting chemicals (TDCs) is the lack of a clear characterization of the dose‐response relationship, especially in the lower region, between disruption of hormones and adverse consequences. The current work correlated early postnatal hypothyroxinemia with hearing loss in the adult rat. Linear regression was performed on the log transform for total serum thyroxine (T4) concentrations on postnatal day 14 or 21 versus dB(SPL) of hearing loss in adult animals developmentally exposed to TDCs. Regression analyses revealed a highly significant correlation between T4 concentration and hearing loss. In the rat, a 50–60% decrease in circulating T4 was needed to significantly impact hearing function. This correlation suggests that T4 serum concentrations at 14 or 21 days of postnatal age may be a good predictive biomarker in rodents of the adverse consequence of developmental exposure to TDCs. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Risk Analysis Wiley

Developmental Disruption of Thyroid Hormone: Correlations with Hearing Dysfunction in Rats

Risk Analysis, Volume 24 (6) – Dec 1, 2004

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Publisher
Wiley
Copyright
Copyright © 2004 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0272-4332
eISSN
1539-6924
DOI
10.1111/j.0272-4332.2004.00557.x
Publisher site
See Article on Publisher Site

Abstract

A wide variety of environmental contaminants adversely affect thyroid hormone (TH) homeostasis. Hypothyroidism and/or hypothyroxinemia during the early postnatal period in the rat leads to permanent structural damage and loss of function in the cochlea. A major uncertainty in assessing the risks of developmental exposure to thyroid‐disrupting chemicals (TDCs) is the lack of a clear characterization of the dose‐response relationship, especially in the lower region, between disruption of hormones and adverse consequences. The current work correlated early postnatal hypothyroxinemia with hearing loss in the adult rat. Linear regression was performed on the log transform for total serum thyroxine (T4) concentrations on postnatal day 14 or 21 versus dB(SPL) of hearing loss in adult animals developmentally exposed to TDCs. Regression analyses revealed a highly significant correlation between T4 concentration and hearing loss. In the rat, a 50–60% decrease in circulating T4 was needed to significantly impact hearing function. This correlation suggests that T4 serum concentrations at 14 or 21 days of postnatal age may be a good predictive biomarker in rodents of the adverse consequence of developmental exposure to TDCs.

Journal

Risk AnalysisWiley

Published: Dec 1, 2004

References

  • Developmental exposure to polychlorinated biphenyls (Aroclor 1254) reduces circulating thyroid hormone concentrations and causes hearing deficits in rats
    Goldey, Goldey; Kehn, Kehn; Lau, Lau; Rhenberg, Rhenberg; Crofton, Crofton
  • Effects of developmental hypothyroidism on auditory and motor function in the rat
    Goldey, Goldey; Kehn, Kehn; Rhenberg, Rhenberg; Crofton, Crofton
  • Mechanistic considerations for the relevance of animal data on thyroid neoplasia to human risk assessment
    McClain, McClain
  • Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy
    Pop, Pop; Kuijpens, Kuijpens; Van Baar, Van Baar; Verkerk, Verkerk; Van Son, Van Son; De Vijlder, De Vijlder; Vulsma, Vulsma; Wiersinga, Wiersinga; Drexhage, Drexhage; Vader, Vader
  • Ontogeny of auditory system function
    Rubel, Rubel

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