Detection of parvovirus B19 DNA, antigen, and particles in the human fetus

Detection of parvovirus B19 DNA, antigen, and particles in the human fetus Human parvovirus B19 commonly infects children, causing erythema infectiosum (fifth disease). However, there is a significant adult population which has not been exposed to the virus and, consequently, does not have protective antibody. Recent reports have associated B19 infection during pregnancy with fetal death, although normal outcome of pregnancy is more common. To characterise further the role of B19 infection in fetal deaths, a series of laboratory investigations has been undertaken on tissues obtained at autopsy. These have demonstrated the presence of virion‐sized DNA by Southern blotting, viral antigen by radioimmunoassay, and viral particles by electron microscopy, all from tissues of hydrops fetalis. These data confirm that the human parvovirus B19 can cross the placenta and replicate in fetal tissues. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Medical Virology Wiley

Detection of parvovirus B19 DNA, antigen, and particles in the human fetus

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Abstract

Human parvovirus B19 commonly infects children, causing erythema infectiosum (fifth disease). However, there is a significant adult population which has not been exposed to the virus and, consequently, does not have protective antibody. Recent reports have associated B19 infection during pregnancy with fetal death, although normal outcome of pregnancy is more common. To characterise further the role of B19 infection in fetal deaths, a series of laboratory investigations has been undertaken on tissues obtained at autopsy. These have demonstrated the presence of virion‐sized DNA by Southern blotting, viral antigen by radioimmunoassay, and viral particles by electron microscopy, all from tissues of hydrops fetalis. These data confirm that the human parvovirus B19 can cross the placenta and replicate in fetal tissues.

Journal

Journal of Medical VirologyWiley

Published: Dec 1, 1987

References

  • Intrauterine infection with human parvovirus
    Bond, Bond; Caul, Caul; Usher, Usher; Cohen, Cohen; Clewley, Clewley; Field, Field
  • Detection of human parvovirus using a molecularly cloned probe
    Clewley, Clewley
  • Human parvovirus and the fetus
    Mortimer, Mortimer; Cohen, Cohen; Buckley, Buckley; Cradock‐Watson, Cradock‐Watson; Ridehalgh, Ridehalgh; Burkhardt, Burkhardt; Schilt, Schilt

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