Decreased Ferritin Levels in Brain in Parkinson's Disease

Decreased Ferritin Levels in Brain in Parkinson's Disease Abstract: Ferritin levels were measured in postmortem brain tissue from patients dying with Parkinson's disease (treated with L‐3,4‐dihydroxyphenylalanine (L‐DOPA)) and from control patients. Ferritin levels were decreased in the substantia nigra, caudate‐putamen, globus pallidus, cerebral cortex, and cerebellum when compared with age‐matched control tissues. However, in CSF from L‐DOPA‐treated patients and in serum from L‐DOPA‐treated and untreated parkinsonian patients, ferritin levels were normal. Previous studies have suggested an increased total iron content in substantia nigra of parkinsonian brain. The failure of substantia nigra ferritin formation to be stimulated by increased iron levels suggests some defect in iron handling in this critical brain region in Parkinson's disease. The reason for decreased ferritin levels throughout the parkinsonian brain is not clear but does not seem to reflect a general system deficit in ferritin. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neurochemistry Wiley

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Publisher
Wiley
Copyright
Copyright © 1990 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0022-3042
eISSN
1471-4159
D.O.I.
10.1111/j.1471-4159.1990.tb08814.x
Publisher site
See Article on Publisher Site

Abstract

Abstract: Ferritin levels were measured in postmortem brain tissue from patients dying with Parkinson's disease (treated with L‐3,4‐dihydroxyphenylalanine (L‐DOPA)) and from control patients. Ferritin levels were decreased in the substantia nigra, caudate‐putamen, globus pallidus, cerebral cortex, and cerebellum when compared with age‐matched control tissues. However, in CSF from L‐DOPA‐treated patients and in serum from L‐DOPA‐treated and untreated parkinsonian patients, ferritin levels were normal. Previous studies have suggested an increased total iron content in substantia nigra of parkinsonian brain. The failure of substantia nigra ferritin formation to be stimulated by increased iron levels suggests some defect in iron handling in this critical brain region in Parkinson's disease. The reason for decreased ferritin levels throughout the parkinsonian brain is not clear but does not seem to reflect a general system deficit in ferritin.

Journal

Journal of NeurochemistryWiley

Published: Jul 1, 1990

References

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