Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Decreased Arteriolar Sensitivity to Shear Stress in Adult Rats is Reversed by Chronic Exercise Activity

Decreased Arteriolar Sensitivity to Shear Stress in Adult Rats is Reversed by Chronic Exercise... Objective: We tested the hypothesis that the decline in endothelium‐dependent arteriolar dilation in adult rats is reversed by chronic exercise activity. Methods: Rats were divided into young (8–10 weeks)‐sedentary (SEDY), adult (29–32 weeks)‐sedentary (SEDA), and adult‐exercised (EXA, treadmill exercise for 18–20 weeks) groups. Responses of isolated arterioles (∼50 µm at 80 mm Hg) of gracilis muscle were assessed to increases in perfusate flow and vasoactive agents. Results: With no differences in basal tone, maximal flow‐induced dilations were not different between arterioles of SEDY and SEDA rats (71 ± 2 and 72 ± 2% of passive diameter, respectively), yet the sensitivity of arterioles to shear stress (WSS50) was significantly less in SEDA than in SEDY rats (35 ± 4 vs. 23 ± 3 dyne/cm2, respectively). In vessels of EXA rats, maximal flow‐induced dilation was significantly augmented (88 ± 2% of passive diameter) and WSS50 (15 ± 1 dyn/cm2) was significantly reduced. Dilation to acetylcholine was enhanced in arterioles of EXA, whereas dilation to sodium nitroprusside was not different in vessels of the three groups. Conclusion: Chronic exercise activity reverses age related reduction in sensitivity of arterioles to increases in wall shear stress. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Microcirculation Wiley

Decreased Arteriolar Sensitivity to Shear Stress in Adult Rats is Reversed by Chronic Exercise Activity

Microcirculation , Volume 9 (2) – Apr 1, 2002

Loading next page...
 
/lp/wiley/decreased-arteriolar-sensitivity-to-shear-stress-in-adult-rats-is-8s67cMo7W1

References (32)

Publisher
Wiley
Copyright
2002 Blackwell
ISSN
1073-9688
eISSN
1549-8719
DOI
10.1038/sj.mn.7800124
Publisher site
See Article on Publisher Site

Abstract

Objective: We tested the hypothesis that the decline in endothelium‐dependent arteriolar dilation in adult rats is reversed by chronic exercise activity. Methods: Rats were divided into young (8–10 weeks)‐sedentary (SEDY), adult (29–32 weeks)‐sedentary (SEDA), and adult‐exercised (EXA, treadmill exercise for 18–20 weeks) groups. Responses of isolated arterioles (∼50 µm at 80 mm Hg) of gracilis muscle were assessed to increases in perfusate flow and vasoactive agents. Results: With no differences in basal tone, maximal flow‐induced dilations were not different between arterioles of SEDY and SEDA rats (71 ± 2 and 72 ± 2% of passive diameter, respectively), yet the sensitivity of arterioles to shear stress (WSS50) was significantly less in SEDA than in SEDY rats (35 ± 4 vs. 23 ± 3 dyne/cm2, respectively). In vessels of EXA rats, maximal flow‐induced dilation was significantly augmented (88 ± 2% of passive diameter) and WSS50 (15 ± 1 dyn/cm2) was significantly reduced. Dilation to acetylcholine was enhanced in arterioles of EXA, whereas dilation to sodium nitroprusside was not different in vessels of the three groups. Conclusion: Chronic exercise activity reverses age related reduction in sensitivity of arterioles to increases in wall shear stress.

Journal

MicrocirculationWiley

Published: Apr 1, 2002

There are no references for this article.