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DAGL‐dependent endocannabinoid signalling: roles in axonal pathfinding, synaptic plasticity and adult neurogenesis

DAGL‐dependent endocannabinoid signalling: roles in axonal pathfinding, synaptic plasticity and... Until recently, endocannabinoid (eCB) signalling was largely studied in the context of synaptic plasticity in the postnatal brain in the absence of detailed knowledge of the nature of the enzyme(s) responsible for the synthesis of the eCBs. However, the identification of two diacylglycerol lipases (DAGLα and DAGLβ) responsible for the synthesis of 2‐arachidonoylglycerol (2‐AG) has increased the understanding of where this eCB is synthesised in relationship to the expression of cannabinoid receptor (CB)1 and CB2. Furthermore, the generation of knockout animals for each enzyme has allowed for the direct testing of their importance for established and emerging eCB functions. Based on this, we now know that DAGLα is enriched in dendritic spines that appose CB1‐positive synaptic terminals, and that 2‐AG functions as a retrograde signal controlling synaptic strength throughout the nervous system. Consequently, we have built on the principle that expression of eCB components dictates function to identify additional physiological functions of this signalling cassette. A number of studies have now provided support for DAGL‐dependent eCB signalling playing important roles in brain development and in cellular plasticity in the adult nervous system. In this article, we will review evidence based on the localisation of the enzymes, as well as from genetic and pharmacological studies, that show DAGL‐dependent eCB signalling to play an important role in axonal growth and guidance during development, in retrograde synaptic signalling at mature synapses, and in the control of adult neurogenesis in the hippocampus and subventricular zone. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Neuroscience Wiley

DAGL‐dependent endocannabinoid signalling: roles in axonal pathfinding, synaptic plasticity and adult neurogenesis

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Publisher
Wiley
Copyright
© 2011 The Authors. European Journal of Neuroscience © 2011 Federation of European Neuroscience Societies and Blackwell Publishing Ltd
ISSN
0953-816X
eISSN
1460-9568
DOI
10.1111/j.1460-9568.2011.07831.x
pmid
22103420
Publisher site
See Article on Publisher Site

Abstract

Until recently, endocannabinoid (eCB) signalling was largely studied in the context of synaptic plasticity in the postnatal brain in the absence of detailed knowledge of the nature of the enzyme(s) responsible for the synthesis of the eCBs. However, the identification of two diacylglycerol lipases (DAGLα and DAGLβ) responsible for the synthesis of 2‐arachidonoylglycerol (2‐AG) has increased the understanding of where this eCB is synthesised in relationship to the expression of cannabinoid receptor (CB)1 and CB2. Furthermore, the generation of knockout animals for each enzyme has allowed for the direct testing of their importance for established and emerging eCB functions. Based on this, we now know that DAGLα is enriched in dendritic spines that appose CB1‐positive synaptic terminals, and that 2‐AG functions as a retrograde signal controlling synaptic strength throughout the nervous system. Consequently, we have built on the principle that expression of eCB components dictates function to identify additional physiological functions of this signalling cassette. A number of studies have now provided support for DAGL‐dependent eCB signalling playing important roles in brain development and in cellular plasticity in the adult nervous system. In this article, we will review evidence based on the localisation of the enzymes, as well as from genetic and pharmacological studies, that show DAGL‐dependent eCB signalling to play an important role in axonal growth and guidance during development, in retrograde synaptic signalling at mature synapses, and in the control of adult neurogenesis in the hippocampus and subventricular zone.

Journal

European Journal of Neuroscience – Wiley

Published: Nov 1, 2011

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  • Bovine brain diacylglycerol lipase: substrate specificity and activation by cyclic AMP‐dependent protein kinase
    Rosenberger, Rosenberger; Farooqui, Farooqui; Horrocks, Horrocks
  • The cannabinoid agonist DALN positively modulates L‐type voltage‐dependent calcium‐channels in N18TG2 neuroblastoma cells
    Rubovitch, Rubovitch; Gafni, Gafni; Sarne, Sarne
  • Endocannabinoids control the induction of cerebellar LTD
    Safo, Safo; Regehr, Regehr
  • Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation
    Sahay, Sahay; Scobie, Scobie; Hill, Hill; O’Carroll, O’Carroll; Kheirbek, Kheirbek; Burghardt, Burghardt; Fenton, Fenton; Dranovsky, Dranovsky; Hen, Hen
  • Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system
    Schlosburg, Schlosburg; Blankman, Blankman; Long, Long; Nomura, Nomura; Pan, Pan; Kinsey, Kinsey; Nguyen, Nguyen; Ramesh, Ramesh; Booker, Booker; Burston, Burston; Thomas, Thomas; Selley, Selley; Sim‐Selley, Sim‐Selley; Liu, Liu; Lichtman, Lichtman; Cravatt, Cravatt
  • The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neurons
    Skaper, Skaper; Buriani, Buriani; Dal Toso, Dal Toso; Petrelli, Petrelli; Romanello, Romanello; Facci, Facci; Leon, Leon
  • A role for adult neurogenesis in spatial long‐term memory
    Snyder, Snyder; Hong, Hong; McDonald, McDonald; Wojtowicz, Wojtowicz
  • Monoacylglycerol lipase limits the duration of endocannabinoid‐mediated depolarization‐induced suppression of excitation in autaptic hippocampal neurons
    Straiker, Straiker; Hu, Hu; Long, Long; Arnold, Arnold; Wager‐Miller, Wager‐Miller; Cravatt, Cravatt; Mackie, Mackie
  • 2‐Arachidonoylglycerol and the cannabinoid receptors
    Sugiura, Sugiura; Waku, Waku
  • Cannabinoid receptors and their endogenous ligands
    Sugiura, Sugiura; Waku, Waku
  • 2‐Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain
    Sugiura, Sugiura; Kondo, Kondo; Sukagawa, Sukagawa; Nakane, Nakane; Shinoda, Shinoda; Itoh, Itoh; Yamashita, Yamashita; Waku, Waku
  • 2‐Arachidonoylglycerol, a putative endogenous cannabinoid receptor ligand, induces rapid, transient elevation of intracellular free Ca 2+ in neuroblastoma x glioma hybrid NG108‐15 cells
    Sugiura, Sugiura; Kodaka, Kodaka; Kondo, Kondo; Tonegawa, Tonegawa; Nakane, Nakane; Kishimoto, Kishimoto; Yamashita, Yamashita; Waku, Waku
  • Is the cannabinoid CB1 receptor a 2‐arachidonoylglycerol receptor? Structural requirements for triggering a Ca 2+ transient in NG108‐15 cells
    Sugiura, Sugiura; Kodaka, Kodaka; Kondo, Kondo; Nakane, Nakane; Kondo, Kondo; Waku, Waku; Ishima, Ishima; Watanabe, Watanabe; Yamamoto, Yamamoto
  • Evidence that the cannabinoid CB1 receptor is a 2‐arachidonoylglycerol receptor. Structure‐activity relationship of 2‐arachidonoylglycerol, ether‐linked analogues, and related compounds
    Sugiura, Sugiura; Kodaka, Kodaka; Nakane, Nakane; Miyashita, Miyashita; Kondo, Kondo; Suhara, Suhara; Takayama, Takayama; Waku, Waku; Seki, Seki; Baba, Baba; Ishima, Ishima
  • Relative activities of rat and dog platelet phospholipase A2 and diglyceride lipase. Selective inhibition of diglyceride lipase by RHC 80267
    Sutherland, Sutherland; Amin, Amin
  • Depolarization‐induced retrograde synaptic inhibition in the mouse cerebellar cortex is mediated by 2‐arachidonoylglycerol
    Szabo, Szabo; Urbanski, Urbanski; Bisogno, Bisogno; Di Marzo, Di Marzo; Mendiguren, Mendiguren; Baer, Baer; Freiman, Freiman
  • The endocannabinoid 2‐arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission
    Tanimura, Tanimura; Yamazaki, Yamazaki; Hashimotodani, Hashimotodani; Uchigashima, Uchigashima; Kawata, Kawata; Abe, Abe; Kita, Kita; Hashimoto, Hashimoto; Shimizu, Shimizu; Watanabe, Watanabe; Sakimura, Sakimura; Kano, Kano
  • Cannabinoid CB1 receptors are localized primarily on cholecystokinin‐containing GABAergic interneurons in the rat hippocampal formation
    Tsou, Tsou; Mackie, Mackie; Sañudo‐Peña, Sañudo‐Peña; Walker, Walker
  • Subcellular arrangement of molecules for 2‐arachidonoyl‐glycerol‐mediated retrograde signaling and its physiological contribution to synaptic modulation in the striatum
    Uchigashima, Uchigashima; Narushima, Narushima; Fukaya, Fukaya; Katona, Katona; Kano, Kano; Watanabe, Watanabe
  • Molecular and morphological configuration for 2‐arachidonoylglycerol‐mediated retrograde signaling at mossy cell‐granule cell synapses in the dentate gyrus
    Uchigashima, Uchigashima; Yamazaki, Yamazaki; Yamasaki, Yamasaki; Tanimura, Tanimura; Sakimura, Sakimura; Kano, Kano; Watanabe, Watanabe
  • Identification and functional characterization of brainstem cannabinoid CB2 receptors
    Van Sickle, Van Sickle; Duncan, Duncan; Kingsley, Kingsley; Mouihate, Mouihate; Urbani, Urbani; Mackie, Mackie; Stella, Stella; Makriyannis, Makriyannis; Piomelli, Piomelli; Davison, Davison; Marnett, Marnett; Di Marzo, Di Marzo; Pittman, Pittman; Patel, Patel; Sharkey, Sharkey
  • Increased neuronal excitability during depolarization‐induced suppression of inhibition in rat hippocampus
    Wagner, Wagner; Alger, Alger
  • Cell adhesion molecules and neuronal regeneration
    Walsh, Walsh; Doherty, Doherty
  • Neural cell adhesion molecules of the immunoglobulin superfamily: role in axon growth and guidance
    Walsh, Walsh; Doherty, Doherty
  • The endocannabinoid receptor, CB1, is required for normal axonal growth and fasciculation
    Watson, Watson; Chambers, Chambers; Hobbs, Hobbs; Doherty, Doherty; Graham, Graham
  • Adult neurogenesis and the olfactory system
    Whitman, Whitman; Greer, Greer
  • Characterisation of the second messenger pathway underlying neurite outgrowth stimulated by FGF
    Williams, Williams; Furness, Furness; Walsh, Walsh; Doherty, Doherty
  • The production of arachidonic acid can account for calcium channel activation in the second messenger pathway underlying neurite outgrowth stimulated by NCAM, N‐cadherin, and L1
    Williams, Williams; Walsh, Walsh; Doherty, Doherty
  • FGF inhibits neurite outgrowth over monolayers of astrocytes and fibroblasts expressing transfected cell adhesion molecules
    Williams, Williams; Mittal, Mittal; Walsh, Walsh; Doherty, Doherty
  • The FGF receptor uses the endocannabinoid signaling system to couple to an axonal growth response
    Williams, Williams; Walsh, Walsh; Doherty, Doherty
  • Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses
    Wilson, Wilson; Nicoll, Nicoll
  • Experimental autoimmune encephalomyelitis disrupts endocannabinoid‐mediated neuroprotection
    Witting, Witting; Chen, Chen; Cudaback, Cudaback; Straiker, Straiker; Walter, Walter; Rickman, Rickman; Moller, Moller; Brosnan, Brosnan; Stella, Stella
  • Requirement of cannabinoid CB(1) receptors in cortical pyramidal neurons for appropriate development of corticothalamic and thalamocortical projections
    Wu, Wu; Zhu, Zhu; Wager‐Miller, Wager‐Miller; Wang, Wang; O’Leary, O’Leary; Monory, Monory; Lutz, Lutz; Mackie, Mackie; Lu, Lu
  • Localization of diacylglycerol lipase‐alpha around postsynaptic spine suggests close proximity between production site of an endocannabinoid, 2‐arachidonoyl‐glycerol, and presynaptic cannabinoid CB1 receptor
    Yoshida, Yoshida; Fukaya, Fukaya; Uchigashima, Uchigashima; Miura, Miura; Kamiya, Kamiya; Kano, Kano; Watanabe, Watanabe
  • Unique inhibitory synapse with particularly rich endocannabinoid signaling machinery on pyramidal neurons in basal amygdaloid nucleus
    Yoshida, Yoshida; Uchigashima, Uchigashima; Yamasaki, Yamasaki; Katona, Katona; Yamazaki, Yamazaki; Sakimura, Sakimura; Kano, Kano; Yoshioka, Yoshioka; Watanabe, Watanabe
  • Activated neural stem cells contribute to stroke‐induced neurogenesis and neuroblast migration toward the infarct boundary in adult rats
    Zhang, Zhang; Zhang, Zhang; Wang, Wang; Wang, Wang; Gousev, Gousev; Zhang, Zhang; Ho, Ho; Morshead, Morshead; Chopp, Chopp
  • CB1 cannabinoid receptor‐mediated neurite remodeling in mouse neuroblastoma N1E‐115 cells
    Zhou, Zhou; Song, Song
  • Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
    Zygmunt, Zygmunt; Petersson, Petersson; Andersson, Andersson; Chuang, Chuang; Sørgård, Sørgård; Di Marzo, Di Marzo; Julius, Julius; Högestätt, Högestätt