Cutaneous sporotrichosis treated with methylene blue‐daylight photodynamic therapy

Cutaneous sporotrichosis treated with methylene blue‐daylight photodynamic therapy Dear Editor,Sporotrichosis is an infection caused by the dimorphic fungus, Sporothrix schenckii. Acquisition typically occurs via cutaneous inoculation with the development of a localized cutaneous and/or lymphocutaneous infection. Antimicrobial photodynamic therapy (aPDT) is a process that generates reactive oxygen species (ROS) in the presence of a photosensitizer, visible light and oxygen which destroys fungal and bacterial cells. Daylight‐PDT (DL‐PDT) uses the visible spectrum of daylight (400–750 nm) for the activation of the photosensitizer instead of an artificial light source. It is currently approved to treat actinic keratosis. The band of absorption of MB is between 550 and 700 nm, with an absorption peak of 654 nm. So the absorption peak of the methylene blue is included in the spectrum of the wavelength of daylight, being an option as a light source.A 41‐year‐old man presented in the outpatient department with a 1‐year history of a plaque on his right arm. Physical examination revealed a 2‐cm, well‐defined erythematous nodule, with suppuration and crust on its surface (Fig. a). No lymphadenopathy was found.(a) Cutaneous sporotrichosis nodule on the right arm. (b) Complete resolution after six sessions of MB‐PDT.Purulent material was submitted for bacterial, fungal and mycobacterial microbiological studies. In sheep blood agar incubation, it was observed the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of the European Academy of Dermatology & Venereology Wiley

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 European Academy of Dermatology and Venereology
ISSN
0926-9959
eISSN
1468-3083
D.O.I.
10.1111/jdv.14545
Publisher site
See Article on Publisher Site

Abstract

Dear Editor,Sporotrichosis is an infection caused by the dimorphic fungus, Sporothrix schenckii. Acquisition typically occurs via cutaneous inoculation with the development of a localized cutaneous and/or lymphocutaneous infection. Antimicrobial photodynamic therapy (aPDT) is a process that generates reactive oxygen species (ROS) in the presence of a photosensitizer, visible light and oxygen which destroys fungal and bacterial cells. Daylight‐PDT (DL‐PDT) uses the visible spectrum of daylight (400–750 nm) for the activation of the photosensitizer instead of an artificial light source. It is currently approved to treat actinic keratosis. The band of absorption of MB is between 550 and 700 nm, with an absorption peak of 654 nm. So the absorption peak of the methylene blue is included in the spectrum of the wavelength of daylight, being an option as a light source.A 41‐year‐old man presented in the outpatient department with a 1‐year history of a plaque on his right arm. Physical examination revealed a 2‐cm, well‐defined erythematous nodule, with suppuration and crust on its surface (Fig. a). No lymphadenopathy was found.(a) Cutaneous sporotrichosis nodule on the right arm. (b) Complete resolution after six sessions of MB‐PDT.Purulent material was submitted for bacterial, fungal and mycobacterial microbiological studies. In sheep blood agar incubation, it was observed the

Journal

Journal of the European Academy of Dermatology & VenereologyWiley

Published: Jan 1, 2018

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