Customized secretion chaperones in pathogenic bacteria

Customized secretion chaperones in pathogenic bacteria Summary Pathogenic yersiniae secrete about a dozen anti‐host proteins, the Yops, by a pathway which does not involve cleavage of a classical signal peptide. The Yop secretory apparatus, called Ysc, for Yop secretion, is the archetype of type III secretion systems (which serve for the secretion of virulence proteins by several animal and plant pathogens) and is related to the flagellar assembly apparatus. The Yop secretion signal is N‐terminal but has not been defined to date. Apart from the Ysc machinery, secretion of at least four Yops requires cytoplasmic proteins called Syc (for specific Yop chaperone). Each Syc protein binds to its cognate Yop. Unlike most cytoplasmic chaperones, these proteins do not have an ATP‐binding domain, and are presumably devoid of ATPase activity. They share a few common properties: an acidic pl, a size in the range of 15–20 kDa, and a putative amphipathic α‐helix in the C‐terminal portion. They were recently shown to have counterparts in other pathogenic bacteria, where they appear to have a similar function. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular Microbiology Wiley

Customized secretion chaperones in pathogenic bacteria

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Publisher
Wiley
Copyright
Copyright © 1996 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0950-382X
eISSN
1365-2958
D.O.I.
10.1111/j.1365-2958.1996.tb02614.x
Publisher site
See Article on Publisher Site

Abstract

Summary Pathogenic yersiniae secrete about a dozen anti‐host proteins, the Yops, by a pathway which does not involve cleavage of a classical signal peptide. The Yop secretory apparatus, called Ysc, for Yop secretion, is the archetype of type III secretion systems (which serve for the secretion of virulence proteins by several animal and plant pathogens) and is related to the flagellar assembly apparatus. The Yop secretion signal is N‐terminal but has not been defined to date. Apart from the Ysc machinery, secretion of at least four Yops requires cytoplasmic proteins called Syc (for specific Yop chaperone). Each Syc protein binds to its cognate Yop. Unlike most cytoplasmic chaperones, these proteins do not have an ATP‐binding domain, and are presumably devoid of ATPase activity. They share a few common properties: an acidic pl, a size in the range of 15–20 kDa, and a putative amphipathic α‐helix in the C‐terminal portion. They were recently shown to have counterparts in other pathogenic bacteria, where they appear to have a similar function.

Journal

Molecular MicrobiologyWiley

Published: Apr 1, 1996

References

  • MxiD, an outer membrane protein necessary for the secretion of the Shigella flexneri Ipa invasins
    Allaoui, Allaoui; Sansonetti, Sansonetti; Parsot, Parsot
  • SecB‐binding does not maintain the translocation‐competent state of prePhoE
    Cock, Cock; Tommassen, Tommassen
  • The chaperone‐like protein YerA of Yersinia pseudotuberculosis stabilizes YopE in the cytoplasm but is dispensible for targeting to the secretion loci
    Frithz‐Lindsten, Frithz‐Lindsten; Rosqvist, Rosqvist; Johansson, Johansson; Forsberg, Forsberg
  • Functional conservation of the Salmonella and Shigella effectors of entry into epithelial cells
    Hermant, Hermant; Ménard, Ménard; Arricau, Arricau; Parsot, Parsot; Popoff, Popoff
  • Chaperone‐assisted assembly and molecular architecture of adhesive pili
    Hultgren, Hultgren; Normark, Normark; Abraham, Abraham
  • Secretion of Yop proteins by Yersiniae
    Michiels, Michiels; Wattiau, Wattiau; Brasseur, Brasseur; Ruysschaert, Ruysschaert; Cornelis, Cornelis
  • Functional organization and nucleotide sequence of virulence region‐2 on the large virulence plasmid in Shigella flexneri 2a
    Sasakawa, Sasakawa; Adler, Adler; Tobe, Tobe; Okada, Okada; Nagai, Nagai; Komatsu, Komatsu; Yoshikawa, Yoshikawa
  • Translocation of a hybrid YopE‐adenylate cyclase from Yersinia enterocolitica into HeLa cells
    Sory, Sory; Cornelis, Cornelis
  • The hrp gene locus of Pseudomonas solanacearum , which controls the production of a type III secretion system, encodes eight proteins related to components of the bacterial flagellar biogenesis complex
    Gijsegem, Gijsegem; Gough, Gough; Zischek, Zischek; Niqueux, Niqueux; Arlat, Arlat; Genin, Genin; Barberis, Barberis; German, German; Castello, Castello; Boucher, Boucher
  • SycE, a chaperone‐like protein of Yersinia enterocolitica involved in the secretion of YopE
    Wattiau, Wattiau; Cornelis, Cornelis

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