Current principles of surgery for retroperitoneal sarcomas

Current principles of surgery for retroperitoneal sarcomas INTRODUCTIONSoft tissue sarcomas (STS) are rare malignant tumors that most commonly arise from cells of mesenchymal origin and can arise in any region of the body. With over 70 different major histologic subtypes and an estimated 12 000 new diagnoses expected in 2017 in the United States, the heterogeneity and rarity of these tumors has made development of evidence‐based guidelines difficult to establish. While STS of the extremity are most common, approximately 15‐20% arise in the retroperitoneum. The primary location of STS is a significant prognostic factor, with tumors of the retroperitoneum having a worse prognosis than those of the trunk or extremity. This is likely due to a combination of factors, including the different histologic distribution of retroperitoneal sarcomas (RPS), their typically larger size at presentation with multi‐organ involvement, and their close proximity to critical structures. RPS may grow insidiously and reach a large size thus presenting rather late as a palpable abdominal mass or alternatively may be discovered during workup of non‐specific abdominal symptoms. Computed tomography (CT) imaging of the abdomen and pelvis is the most useful initial imaging modality to evaluate the extent of adjacent organ involvement and to rule out intra‐abdominal metastatic disease. Biopsy to confirm http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Surgical Oncology Wiley

Current principles of surgery for retroperitoneal sarcomas

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Publisher
Wiley
Copyright
© 2018 Wiley Periodicals, Inc.
ISSN
0022-4790
eISSN
1096-9098
D.O.I.
10.1002/jso.24919
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONSoft tissue sarcomas (STS) are rare malignant tumors that most commonly arise from cells of mesenchymal origin and can arise in any region of the body. With over 70 different major histologic subtypes and an estimated 12 000 new diagnoses expected in 2017 in the United States, the heterogeneity and rarity of these tumors has made development of evidence‐based guidelines difficult to establish. While STS of the extremity are most common, approximately 15‐20% arise in the retroperitoneum. The primary location of STS is a significant prognostic factor, with tumors of the retroperitoneum having a worse prognosis than those of the trunk or extremity. This is likely due to a combination of factors, including the different histologic distribution of retroperitoneal sarcomas (RPS), their typically larger size at presentation with multi‐organ involvement, and their close proximity to critical structures. RPS may grow insidiously and reach a large size thus presenting rather late as a palpable abdominal mass or alternatively may be discovered during workup of non‐specific abdominal symptoms. Computed tomography (CT) imaging of the abdomen and pelvis is the most useful initial imaging modality to evaluate the extent of adjacent organ involvement and to rule out intra‐abdominal metastatic disease. Biopsy to confirm

Journal

Journal of Surgical OncologyWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

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