Epoxides are highly challenging alkylating reagents for the Catellani reaction. In their Communication on page 3444, Q. Zhou and co‐workers report a cooperative catalytic system comprising of a PdII/XPhos complex and the potassium salt of 5‐norbornene‐2‐carboxylic acid to enable the use of epoxides as alkylating reagents in the Catellani reaction. The picture shows the key elements of this novel transformation, with representative buildings of Wuhan University in the background. Cover design by Jun Deng, Wuhan University.Nitrogen‐Based Lewis AcidsD. W. Stephan and co‐workers show in their Communication on page 3322 ff. that a cyclic (alkyl)(amino) nitrenium featuring a cationic nitrogen atom has enhanced electrophilicity.Reaction KineticsChemicals can be released to a solution reaction from a piece of ice, as described by B. Ge, L.‐M. Liu, H. Wu et al. in their Communication on page 3354 ff. By this simple ice‐melting process, nuclei formation and growth can be successfully suppressed.Natural ProductsIn their Communication on page 3386 ff., J. Xu et al. report the first total synthesis of astellatol, which was first discovered three decades ago. The synthesis is enantiospecific and access to the bicyclic core is efficient.
Angewandte Chemie International Edition – Wiley
Published: Jan 19, 2018
Keywords: ; ; ; ;
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