Correlation of quantitative parameters of magnetic resonance perfusion‐weighted imaging with vascular endothelial growth factor, microvessel density and hypoxia‐inducible factor‐1α in nasopharyngeal carcinoma: Evaluation on radiosensitivity study

Correlation of quantitative parameters of magnetic resonance perfusion‐weighted imaging with... KeypointsA prospective study showed that the correlation of parameters of magnetic resonance perfusion‐weighted imaging (MR‐PWI) with the expression of VEGF, HIF‐1α and MVD in nasopharyngeal carcinoma.Tumor microenvironment has a certain influence on radiosensitivity of cells, and oxygen level play an important role.Magnetic resonance perfusion‐weighted imaging (MR‐PWI) with the expression of VEGF, HIF‐1α and MVD may be used in further studies of predicting radiosensitivity in tumors.INTRODUCTIONNasopharyngeal carcinoma (NPC) is common head and neck malignant tumour among Asians, especially in the South of China. The main treatment for NPC is radiotherapy (RT) alone for early‐stage (T1N0) disease. Although early‐stage NPC is highly curable, the treatment results of conventional RT and fractionation are unsatisfactory for patients with advanced locoregional NPC. Therefore, combined radiotherapy and chemotherapy became extensively recommended as the standard treatment for more advanced lesions. Concurrent chemoradiotherapy (CRT) has been shown to improve survival for Stages III‐IV disease comparing RT alone in the Intergroup 0099 study (IGS). The control rate for patients with Stages T1 and T2 disease by American Joint Committee on Cancer (AJCC) 1992 ranged from 64% to 95%; however, the control rate decreased to 44%‐68% in T3/T4 tumours.Hypoxia‐inducible factor 1 (HIF‐1) is a heterodimeric transcriptional factors composed of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Otolaryngology Wiley

Correlation of quantitative parameters of magnetic resonance perfusion‐weighted imaging with vascular endothelial growth factor, microvessel density and hypoxia‐inducible factor‐1α in nasopharyngeal carcinoma: Evaluation on radiosensitivity study

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 John Wiley & Sons Ltd
ISSN
1749-4478
eISSN
1749-4486
D.O.I.
10.1111/coa.12982
Publisher site
See Article on Publisher Site

Abstract

KeypointsA prospective study showed that the correlation of parameters of magnetic resonance perfusion‐weighted imaging (MR‐PWI) with the expression of VEGF, HIF‐1α and MVD in nasopharyngeal carcinoma.Tumor microenvironment has a certain influence on radiosensitivity of cells, and oxygen level play an important role.Magnetic resonance perfusion‐weighted imaging (MR‐PWI) with the expression of VEGF, HIF‐1α and MVD may be used in further studies of predicting radiosensitivity in tumors.INTRODUCTIONNasopharyngeal carcinoma (NPC) is common head and neck malignant tumour among Asians, especially in the South of China. The main treatment for NPC is radiotherapy (RT) alone for early‐stage (T1N0) disease. Although early‐stage NPC is highly curable, the treatment results of conventional RT and fractionation are unsatisfactory for patients with advanced locoregional NPC. Therefore, combined radiotherapy and chemotherapy became extensively recommended as the standard treatment for more advanced lesions. Concurrent chemoradiotherapy (CRT) has been shown to improve survival for Stages III‐IV disease comparing RT alone in the Intergroup 0099 study (IGS). The control rate for patients with Stages T1 and T2 disease by American Joint Committee on Cancer (AJCC) 1992 ranged from 64% to 95%; however, the control rate decreased to 44%‐68% in T3/T4 tumours.Hypoxia‐inducible factor 1 (HIF‐1) is a heterodimeric transcriptional factors composed of

Journal

Clinical OtolaryngologyWiley

Published: Jan 1, 2018

Keywords: ; ; ; ; ; ; ;

References

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