CORRELATION OF PLASMA AND BRAIN AMINO ACID AND PUTATIVE NEUROTRANSMITTER ALTERATIONS DURING ACUTE HEPATIC COMA IN THE RAT

CORRELATION OF PLASMA AND BRAIN AMINO ACID AND PUTATIVE NEUROTRANSMITTER ALTERATIONS DURING ACUTE... Abstract— During acute hepatic coma following two‐stage hepatic devascularization in the rat, profound changes occurred in plasma and whole‐brain amino acids and putative neurotransmitters. Brain ammonia, glutamine and GABA were increased, aspartate was decreased, while glutamate was unchanged. An increase in brain tryptophan was accompanied by a similar increase in plasma unbound tryptophan but decreased plasma total tryptophan. These changes occurred in the presence of high plasma levels of the other neutral amino acids, including the branched chain amino acids. Plasma insulin was unchanged while glucagon levels rose, resulting in a decreased insulin to glucagon ratio. These results suggest that while plasma unbound tryptophan may influence brain tryptophan levels, altered plasma concentrations of neutral amino acids which compete with tryptophan for transport into the brain do not contribute to the increase in brain tryptophan observed during acute hepatic coma. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neurochemistry Wiley

CORRELATION OF PLASMA AND BRAIN AMINO ACID AND PUTATIVE NEUROTRANSMITTER ALTERATIONS DURING ACUTE HEPATIC COMA IN THE RAT

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Publisher
Wiley
Copyright
Copyright © 1979 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0022-3042
eISSN
1471-4159
DOI
10.1111/j.1471-4159.1979.tb00350.x
Publisher site
See Article on Publisher Site

Abstract

Abstract— During acute hepatic coma following two‐stage hepatic devascularization in the rat, profound changes occurred in plasma and whole‐brain amino acids and putative neurotransmitters. Brain ammonia, glutamine and GABA were increased, aspartate was decreased, while glutamate was unchanged. An increase in brain tryptophan was accompanied by a similar increase in plasma unbound tryptophan but decreased plasma total tryptophan. These changes occurred in the presence of high plasma levels of the other neutral amino acids, including the branched chain amino acids. Plasma insulin was unchanged while glucagon levels rose, resulting in a decreased insulin to glucagon ratio. These results suggest that while plasma unbound tryptophan may influence brain tryptophan levels, altered plasma concentrations of neutral amino acids which compete with tryptophan for transport into the brain do not contribute to the increase in brain tryptophan observed during acute hepatic coma.

Journal

Journal of NeurochemistryWiley

Published: Feb 1, 1979

References

  • Regional brain indoleamine metabolism following chronic portacaval anastomosis in the rat
    Cummings, Cummings; Soeters, Soeters; James, James; Keake, Keake; Fischer, Fischer
  • Regional brain study of indoleamine metabolism in the rat in acute hepatic failure
    Cummings, Cummings; James, James; Soeters, Soeters; Keane, Keane; Foster, Foster; Fischer, Fischer
  • Plasma and brain tryptophan changes in experimental acute hepatic failure
    Curzon, Curzon; Kantamaneni, Kantamaneni; Winch, Winch; Roias‐Bueno, Roias‐Bueno; Murray‐Lyon, Murray‐Lyon; Williams, Williams
  • CNS at the cellular level: identity of transmitter agents
    Hebb, Hebb
  • Portacaval shunt in the rat
    Lee, Lee; Fischer, Fischer
  • Ions and the transport of gamma‐aminobutyric acid by synaptosomes
    Martin, Martin; Smith, Smith
  • Plasma and brain amino acids in fulminant hepatic Failure and their relationship to hepatic encephalopathy
    Record, Record; Buxton, Buxton; Chase, Chase; Curzon, Curzon; Murray‐Lyon, Murray‐Lyon; Williams, Williams

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