Abstract: In extensively washed rat cortical membranes (3 H)(+)‐ 5 ‐ methyl ‐ 10,11 ‐ dihydro ‐ 5 H‐ dibenzo (a,d)cyclohepten‐5,10‐imine ((3H)MK‐801) labeled a homogeneous set of sites (Bmax=1.86 pmol/mg protein) with relatively low affinity (KD= 45 nM). l‐Glutamate, glycine. and spermidine produced concentration‐dependent increases in specific (3H)MK‐801 binding due to a reduction in the Kd of the radioligand. In the presence of high concentrations of l‐glutamate, glycine, or spermidine, the KD values for (3H)MK‐801 were reduced to 11 nM, 18 nM, and 15 nM, respectively. Maximally effective concentrations of combinations of the three compounds further increased (3H)MK‐801 binding affinity as follows: l‐glutamate + glycine, KD= 6.2 nM; l‐glutamate + spermidine, KD= 2.2 nM:
Journal of Neurochemistry – Wiley
Published: Sep 1, 1988
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