Control and integration of cell signaling pathways during C. Elegans vulval development

Control and integration of cell signaling pathways during C. Elegans vulval development Vulval development in the Caenorhabditis elegans hermaphrodite represents a simple, genetically tractable system for studying how cell signaling events control cell fata decisions. Current models suggest that proper specification of vulval cell fates relies on the integration of multiple signaling systems, including one that involves a receptor tyrosine kinase (RTK)→Ras→mitogen activated protein kinase (MAPK) cascade and one that involves a LIN‐12/Notch family receptor. In this review, we first discuss how genetic strategies are being used to identify and analyze components that control vulval cell fate decisions. We then describe the different signaling systems that have been elucidated and how they relate to one another. Finally, we highlight several recently characterized genes that encode positive regulators, negative regulators or potential targets of the RTK→Ras→MAPK cascade involved in vulval induction. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png BioEssays Wiley

Control and integration of cell signaling pathways during C. Elegans vulval development

BioEssays, Volume 18 (6) – Jun 1, 1996

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Publisher
Wiley
Copyright
Copyright © 1996 Cambridge University Press
ISSN
0265-9247
eISSN
1521-1878
DOI
10.1002/bies.950180609
Publisher site
See Article on Publisher Site

Abstract

Vulval development in the Caenorhabditis elegans hermaphrodite represents a simple, genetically tractable system for studying how cell signaling events control cell fata decisions. Current models suggest that proper specification of vulval cell fates relies on the integration of multiple signaling systems, including one that involves a receptor tyrosine kinase (RTK)→Ras→mitogen activated protein kinase (MAPK) cascade and one that involves a LIN‐12/Notch family receptor. In this review, we first discuss how genetic strategies are being used to identify and analyze components that control vulval cell fate decisions. We then describe the different signaling systems that have been elucidated and how they relate to one another. Finally, we highlight several recently characterized genes that encode positive regulators, negative regulators or potential targets of the RTK→Ras→MAPK cascade involved in vulval induction.

Journal

BioEssaysWiley

Published: Jun 1, 1996

References

  • Intercellular signaling and signal transduction in C. elegans
    Sternberg, Sternberg
  • Isolation and genetic characterization of cell‐lineage mutants of the nematode Caenorhabditis elegans
    Horvitz, Horvitz; Sulston, Sulston
  • Identification and characterization of 22 genes that affect the vulval cell lineages of Caenorhabditis elegans
    Ferguson, Ferguson; Horvitz, Horvitz
  • Multiple functions of let‐23 , a Caenorhabditis elegans receptor tyrosine kinase gene required for vulval induction
    Aroian, Aroian; Sternberg, Sternberg
  • sli‐1 , a negative regulator of let‐23 ‐mediated signaling in C. elegans
    Jongeward, Jongeward; Clandinin, Clandinin; Sternberg, Sternberg
  • Ras pathways in Caenorhabditis elegans
    Kayne, Kayne; Sternberg, Sternberg
  • The Caenorhabditis elegans locus lin‐15 , a negative regulator of a tyrosine kinase signaling pathway, encodes two different proteins
    Clark, Clark; Lu, Lu; Horvitz, Horvitz
  • The ncl‐1 gene and genetic mosaics of Caenorhabditis elegans
    Hedgecock, Hedgecock; Herman, Herman

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